Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration (Q38170259)

30 August 2017

title

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration (English)

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30 August 2017

Nick Barker

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30 August 2017

publication date

11 December 2013

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Nature Reviews Molecular Cell Biology

30 August 2017

published in

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30 August 2017

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30 August 2017

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30 August 2017

page(s)

19-33

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Renewal of cell populations

30 August 2017

cites work

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31 March 2020

The intestinal stem cell

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The stem cells of small intestinal crypts: where are they?

31 March 2020

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Unravelling stem cell dynamics by lineage tracing

31 March 2020

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Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications

31 March 2020

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Tissue-resident adult stem cell populations of rapidly self-renewing organs

31 March 2020

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Intestinal label-retaining cells are secretory precursors expressing Lgr5.

31 March 2020

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A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

31 March 2020

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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

31 March 2020

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The intestinal epithelium tuft cells: specification and function

31 March 2020

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TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function

31 March 2020

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Gastrointestinal stem cells. II. Intestinal stem cells

31 March 2020

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Cellular inheritance of a Cre-activated reporter gene to determine Paneth cell longevity in the murine small intestine

31 March 2020

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Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis

31 March 2020

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Wnt signaling in the intestinal epithelium: from endoderm to cancer

31 March 2020

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Epithelial hedgehog signals pattern the intestinal crypt-villus axis.

31 March 2020

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

31 March 2020

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Whole population cell kinetics and postnatal development of the mouse intestinal epithelium

31 March 2020

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Expansion of intestinal epithelial stem cells during murine development

31 March 2020

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Identification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium

31 March 2020

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Optimality in the development of intestinal crypts

31 March 2020

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Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury

31 March 2020

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Derivation of mouse intestinal crypts from single progenitor cells

31 March 2020

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Chimeric-transgenic mice represent a powerful tool for studying how the proliferation and differentiation programs of intestinal epithelial cell lineages are regulated

31 March 2020

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Clonal analysis of mouse intestinal epithelial progenitors.

31 March 2020

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Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.

31 March 2020

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Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

31 March 2020

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Mitochondrial DNA mutations in human colonic crypt stem cells

31 March 2020

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Polyclonal origin of colonic adenomas in an XO/XY patient with FAP.

31 March 2020

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The clonogen content of murine intestinal crypts: dependence on radiation dose used in its determination

31 March 2020

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A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy

31 March 2020

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The stem-cell zone of the small intestinal epithelium. III. Evidence from columnar, enteroendocrine, and mucous cells in the adult mouse

31 March 2020

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Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

31 March 2020

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A clonal marker induced by mutation in mouse intestinal epithelium

31 March 2020

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Cell proliferation studies in the intestinal epithelium of the rat. I. Determination of the kinetic parameters

31 March 2020

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Mutation selection and the natural history of cancer

31 March 2020

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The intestinal epithelial stem cell: the mucosal governor

31 March 2020

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types

31 March 2020

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell.

31 March 2020

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. III. Entero-endocrine cells.

31 March 2020

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells

31 March 2020

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. II. Mucous cells

31 March 2020

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Identification of stem cells in small intestine and colon by marker gene Lgr5

31 March 2020

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

31 March 2020

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Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation

31 March 2020

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Immortal strands? Give me a break

31 March 2020

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Isolation and in vitro expansion of human colonic stem cells.

31 March 2020

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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

31 March 2020

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The Intestinal Wnt/TCF Signature.

31 March 2020

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Transcription factor achaete scute-like 2 controls intestinal stem cell fate

31 March 2020

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

31 March 2020

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

31 March 2020

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LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling

31 March 2020

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

31 March 2020

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

31 March 2020

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

31 March 2020

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Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.

31 March 2020

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The structural basis of R-spondin recognition by LGR5 and RNF43

31 March 2020

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Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5

31 March 2020

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

31 March 2020

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Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

31 March 2020

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Intestinal stem cell replacement follows a pattern of neutral drift

31 March 2020

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Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

31 March 2020

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The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

31 March 2020

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Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

31 March 2020

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Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

31 March 2020

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Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism

31 March 2020

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On the biomechanics of stem cell niche formation in the gut--modelling growing organoids

31 March 2020

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A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt

31 March 2020

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DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

31 March 2020

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Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

31 March 2020

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ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

31 March 2020

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Bmi1 is expressed in vivo in intestinal stem cells

31 March 2020

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The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

31 March 2020

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Single-molecule transcript counting of stem-cell markers in the mouse intestine

31 March 2020

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Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

31 March 2020

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The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor

31 March 2020

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Interconversion between intestinal stem cell populations in distinct niches

31 March 2020

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Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

31 March 2020

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Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

31 March 2020

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Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells

31 March 2020

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Deduction of the clonogen content of intestinal crypts: a direct comparison of two-dose and multiple-dose methodologies

31 March 2020

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

31 March 2020

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Paneth cells in intestinal homeostasis and tissue injury

31 March 2020

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Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

31 March 2020

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Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells

31 March 2020

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Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice

31 March 2020

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Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).

31 March 2020

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Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

31 March 2020

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Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

31 March 2020

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Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice

31 March 2020

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SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

31 March 2020

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Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

31 March 2020

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Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium

31 March 2020

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Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

31 March 2020

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Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.

31 March 2020

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Sox9 expression marks a subset of CD24-expressing small intestine epithelial stem cells that form organoids in vitro

31 March 2020

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Identification of a putative intestinal stem cell and early lineage marker; musashi-1.

31 March 2020

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Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine

31 March 2020

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Brief report: musashi1-eGFP mice, a new tool for differential isolation of the intestinal stem cell populations

31 March 2020

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Musashi1-CreER(T2) : a new cre line for conditional mutagenesis in neural stem cells

31 March 2020

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

31 March 2020

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

31 March 2020

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Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine

31 March 2020

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Identifying the stem cell of the intestinal crypt: strategies and pitfalls

31 March 2020

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PTEN-deficient intestinal stem cells initiate intestinal polyposis

31 March 2020

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BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

31 March 2020

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Re-examination of P-PTEN staining patterns in the intestinal crypt

31 March 2020

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Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.

31 March 2020

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Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches

31 March 2020

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Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice

31 March 2020

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Doublecortin and CaM kinase-like-1 and leucine-rich-repeat-containing G-protein-coupled receptor mark quiescent and cycling intestinal stem cells, respectively

31 March 2020

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DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium

31 March 2020

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Dclk1 distinguishes between tumor and normal stem cells in the intestine

31 March 2020

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

31 March 2020

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A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse

31 March 2020

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Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

31 March 2020

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An allelic difference determines reciprocal patterns of expression of binding sites for Dolichos biflorus lectin in inbred strains of mice

31 March 2020

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12 December 2020

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

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12 December 2020

Clonal analysis of intestinal crypt populations in mouse aggregation chimaeras

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12 December 2020

Cell migration in the small and large bowel shows a strong circadian rhythm

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12 December 2020

AC133, a novel marker for human hematopoietic stem and progenitor cells

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12 December 2020

Scanning electron microscopy of isolated epithelium of the murine gastrointestinal tract: morphology of the basal surface and evidence for paracrinelike cells

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12 December 2020

Identifiers

DOI

10.1038/NRM3721

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Dimensions Publication ID

30 August 2017

1051868900

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