Histone lysine demethylases as targets for anticancer therapy (Q38162717)

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

Epigenetic protein families: a new frontier for drug discovery

21 January 2018

1 reference

Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription

21 January 2018

1 reference

Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

1 reference

Histone lysine methylation dynamics: establishment, regulation, and biological impact

21 January 2018

1 reference

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

1 reference

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

1 reference

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

21 January 2018

1 reference

The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

21 January 2018

1 reference

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

21 January 2018

1 reference

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

Histone methyltransferases in cancer

21 January 2018

1 reference

Histone methylation: a dynamic mark in health, disease and inheritance

21 January 2018

1 reference

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

1 reference

Role for Dpy-30 in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent Domains

21 January 2018

1 reference

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

21 January 2018

1 reference

Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

1 reference

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

1 reference

SnapShot: Histone-modifying enzymes

21 January 2018

1 reference

Readers of histone modifications

21 January 2018

1 reference

High-resolution genome-wide mapping of the primary structure of chromatin

21 January 2018

1 reference

Histone modification: cause or cog?

21 January 2018

1 reference

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

Histone demethylation by a family of JmjC domain-containing proteins

21 January 2018

1 reference

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

21 January 2018

1 reference

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

Molecular mechanisms and potential functions of histone demethylases

21 January 2018

1 reference

In vivo residue-specific histone methylation dynamics

21 January 2018

1 reference

Fast signals and slow marks: the dynamics of histone modifications

21 January 2018

1 reference

A novel mammalian flavin-dependent histone demethylase

21 January 2018

1 reference

Oxidation of amines by flavoproteins

21 January 2018

1 reference

The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities

21 January 2018

1 reference

Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

21 January 2018

1 reference

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

21 January 2018

1 reference

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

21 January 2018

1 reference

LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation

21 January 2018

1 reference

p53 is regulated by the lysine demethylase LSD1

21 January 2018

1 reference

Lysine methylation regulates E2F1-induced cell death

21 January 2018

1 reference

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

21 January 2018

1 reference

Structural and functional differences of SWIRM domain subtypes

21 January 2018

1 reference

Structural insight into substrate recognition by histone demethylase LSD2/KDM1b

21 January 2018

1 reference

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b

21 January 2018

1 reference

Regulation of LSD1 histone demethylase activity by its associated factors

21 January 2018

1 reference

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

21 January 2018

1 reference

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

21 January 2018

1 reference

Structural studies on human 2-oxoglutarate dependent oxygenases

21 January 2018

1 reference

Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

21 January 2018

1 reference

The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes

21 January 2018

1 reference

JmjC-domain-containing proteins and histone demethylation

21 January 2018

1 reference

Structural basis for human PHF2 Jumonji domain interaction with metal ions

21 January 2018

1 reference

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

21 January 2018

1 reference

Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation

21 January 2018

1 reference

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

21 January 2018

1 reference

Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function

21 January 2018

1 reference

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

21 January 2018

1 reference

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

21 January 2018

1 reference

Structural basis of the recognition of a methylated histone tail by JMJD2A

21 January 2018

1 reference

Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase

21 January 2018

1 reference

Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases

21 January 2018

1 reference

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

21 January 2018

1 reference

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

21 January 2018

1 reference

The mutational landscape of lethal castration-resistant prostate cancer

21 January 2018

1 reference

Clinical, immunophenotypic, cytogenetic, and molecular genetic features in 117 adult patients with mixed-phenotype acute leukemia defined by WHO-2008 classification

21 January 2018

1 reference

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

21 January 2018

1 reference

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

1 reference

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

1 reference

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

21 January 2018

1 reference

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

1 reference

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

21 January 2018

1 reference

Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

21 January 2018

1 reference

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

21 January 2018

1 reference

Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

21 January 2018

1 reference

The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth

21 January 2018

1 reference

HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

21 January 2018

1 reference

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

Cooperative epigenetic modulation by cancer amplicon genes

21 January 2018

1 reference

The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3

21 January 2018

1 reference

Jarid1b targets genes regulating development and is involved in neural differentiation

21 January 2018

1 reference

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

21 January 2018

1 reference

PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?

21 January 2018

1 reference

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

21 January 2018

1 reference

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

21 January 2018

1 reference

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

21 January 2018

1 reference

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

21 January 2018

1 reference

Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

21 January 2018

1 reference

KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

21 January 2018

1 reference

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

21 January 2018

1 reference

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

1 reference

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

21 January 2018

1 reference

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

21 January 2018

1 reference

Monoamine oxidase: from genes to behavior

21 January 2018

1 reference

Identification of cell-active lysine specific demethylase 1-selective inhibitors

21 January 2018

1 reference

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

21 January 2018

1 reference

Brain-penetrant LSD1 inhibitors can block memory consolidation.

21 January 2018

1 reference

Inhibitors of histone demethylases

21 January 2018

1 reference

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

1 reference

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

21 January 2018

1 reference

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

21 January 2018

1 reference

Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

21 January 2018

1 reference

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

1 reference

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

21 January 2018

1 reference

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

21 January 2018

1 reference

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

21 January 2018

1 reference

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

21 January 2018

1 reference

Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer

21 January 2018

1 reference

Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

1 reference

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

21 January 2018

1 reference

CoREST is an integral component of the CoREST- human histone deacetylase complex

21 January 2018

1 reference

A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

21 January 2018

1 reference

Functional interplay between histone demethylase and deacetylase enzymes

21 January 2018

1 reference

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

21 January 2018

1 reference

Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors

21 January 2018

1 reference

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

21 January 2018

1 reference

The language of covalent histone modifications

21 January 2018

1 reference

Crystal structure and mechanism of human lysine-specific demethylase-1.

21 January 2018

1 reference

Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study

21 January 2018

1 reference

Concerted hydrogen atom and electron transfer mechanism for catalysis by lysine-specific demethylase.

21 January 2018

1 reference

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

1 reference

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

21 January 2018

1 reference

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

21 January 2018

1 reference

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

21 January 2018

1 reference

Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

21 January 2018

1 reference

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

21 January 2018

1 reference

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

21 January 2018

1 reference

Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis

21 January 2018

1 reference

Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells

21 January 2018

1 reference

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

21 January 2018

1 reference

The expression of histone demethylase JMJD1A in renal cell carcinoma

21 January 2018

1 reference

The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice

21 January 2018

1 reference

Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor

21 January 2018

1 reference

Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.

21 January 2018

1 reference

The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility

21 January 2018

1 reference

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

21 January 2018

1 reference

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

21 January 2018

1 reference

The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

21 January 2018

1 reference

Phenotypic annotation of the mouse X chromosome

21 January 2018

1 reference

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

21 January 2018

1 reference

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

21 January 2018

1 reference

Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome

21 January 2018

1 reference

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

21 January 2018

1 reference

FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway

21 January 2018

1 reference

Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma

21 January 2018

1 reference

Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck

21 January 2018

1 reference

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

1 reference

A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

21 January 2018

1 reference

Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

21 January 2018

1 reference

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

21 January 2018

1 reference

Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia

21 January 2018

1 reference

Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

21 January 2018

1 reference

A novel mutation in JARID1C gene associated with mental retardation

21 January 2018

1 reference

Novel JARID1C/SMCX mutations in patients with X-linked mental retardation

21 January 2018

1 reference

A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.

21 January 2018

1 reference

A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay.

21 January 2018

1 reference

jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background

21 January 2018

1 reference

MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

21 January 2018

1 reference

Molecular mechanisms and potential functions of histone demethylases

21 January 2018

1 reference

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

31 March 2020

1 reference

An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

31 March 2020

1 reference

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

31 March 2020

1 reference

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

31 March 2020

1 reference

Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression

31 March 2020

1 reference

The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis

31 March 2020

1 reference

A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)

31 March 2020

1 reference

Deletion of Y-chromosome specific genes in human prostate cancer

31 March 2020

1 reference

12 December 2020

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

1 reference

12 December 2020

Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer

1 reference

12 December 2020

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

1 reference

12 December 2020

Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection

1 reference

12 December 2020

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines

1 reference

12 December 2020

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

1 reference

12 December 2020

Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer

1 reference

12 December 2020

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

1 reference

12 December 2020

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

1 reference

12 December 2020

PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells

1 reference

12 December 2020

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

1 reference

12 December 2020