Mechanisms of resistance to therapies targeting BRCA-mutant cancers (Q38160737)

30 August 2017

title

Mechanisms of resistance to therapies targeting BRCA-mutant cancers (English)

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30 August 2017

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30 August 2017

Alan Ashworth

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30 August 2017

language of work or name

English

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publication date

7 October 2013

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30 August 2017

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30 August 2017

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30 August 2017

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30 August 2017

page(s)

1381-1388

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Clonal evolution in cancer

30 August 2017

cites work

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The emerging landscape of breast cancer susceptibility

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

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Integrating Genetic Approaches into the Discovery of Anticancer Drugs

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The concept of synthetic lethality in the context of anticancer therapy

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

21 January 2018

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

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Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers

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The DNA damage response and cancer therapy

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Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

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MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

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Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

21 January 2018

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PARP-1 inhibition as a targeted strategy to treat Ewing's sarcoma

21 January 2018

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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

21 January 2018

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Resistance to therapy caused by intragenic deletion in BRCA2

21 January 2018

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Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

21 January 2018

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Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

21 January 2018

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Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

21 January 2018

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6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance

21 January 2018

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A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

21 January 2018

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BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

21 January 2018

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

21 January 2018

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53BP1 regulates DSB repair using Rif1 to control 5' end resection

21 January 2018

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Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching

21 January 2018

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RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.

21 January 2018

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A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

21 January 2018

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RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.

21 January 2018

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53BP1 expression in sporadic and inherited ovarian carcinoma: Relationship to genetic status and clinical outcomes.

21 January 2018

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

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Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

21 January 2018

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

21 January 2018

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Role of poly(ADP-ribose) formation in DNA repair

21 January 2018

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BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency

21 January 2018

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A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

21 January 2018

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Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.

21 January 2018

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Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways

21 January 2018

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Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells

21 January 2018

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BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

21 January 2018

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A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

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A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer

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Principles of cancer therapy: oncogene and non-oncogene addiction

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Evolutionary plasticity of genetic interaction networks

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The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

21 January 2018

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Functional viability profiles of breast cancer

21 January 2018

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Secondary mutations inBRCA2associated with clinical resistance to a PARP inhibitor

21 January 2018

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Genetic Interactions in Cancer Progression and Treatment

21 January 2018

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12 December 2020

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

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12 December 2020

Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura

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12 December 2020

Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2

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12 December 2020

Higher cytoplasmic and nuclear poly(ADP-ribose) polymerase expression in familial than in sporadic breast cancer

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12 December 2020

ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development.

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12 December 2020

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3369

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30 August 2017

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