Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer (Q24302687)

19 October 2023

Bushra Ateeq

Bushra

Ateeq

1 reference

19 October 2023

Irfan A Asangani

Irfan A

Asangani

1 reference

Sooryanarayana Varambally

19 October 2023

object named as

Sooryanarayana Varambally

Sooryanarayana

Varambally

1 reference

19 October 2023

Nallasivam Palanisamy

object named as

Nallasivam Palanisamy

Nallasivam

Palanisamy

1 reference

19 October 2023

Kenneth J Pienta

Kenneth J

Pienta

1 reference

19 October 2023

Arul M Chinnaiyan

Arul M

Chinnaiyan

1 reference

19 October 2023

Christopher A Maher

Christopher A

Maher

1 reference

19 October 2023

Scott A Tomlins

Scott A

Tomlins

1 reference

19 October 2023

Xuhong Cao

Xuhong

Cao

1 reference

19 October 2023

Robert J Lonigro

Robert J

Lonigro

1 reference

19 October 2023

J Chad Brenner

J Chad

Brenner

1 reference

19 October 2023

Xiaoju Wang

Xiaoju

Wang

1 reference

19 October 2023

Anastasia K Yocum

Anastasia K

Yocum

1 reference

19 October 2023

Felix Y Feng

Felix Y

Feng

1 reference

19 October 2023

Hallie Liang

Hallie

Liang

1 reference

19 October 2023

Venkatesha Basrur

Venkatesha

Basrur

1 reference

19 October 2023

Kojo Elenitoba-Johnson

object named as

Kojo S J Elenitoba-Johnson

Kojo S J

Elenitoba-Johnson

1 reference

19 October 2023

Maha Hussain

Maha

Hussain

1 reference

19 October 2023

Nora M Navone

Nora M

Navone

1 reference

19 October 2023

Aaron Sabolch

Aaron

Sabolch

1 reference

19 October 2023

Yong Li

Yong

1 reference

19 October 2023

Sonam Patel

Sonam

Patel

1 reference

19 October 2023

Jindan Yu

Jindan

1 reference

19 October 2023

Javed Siddiqui

Javed

Siddiqui

1 reference

19 October 2023

Wei Yan

Wei

Yan

1 reference

19 October 2023

Rohit Mehra

Rohit

Mehra

1 reference

19 October 2023

Jun Yang

Jun

Yang

1 reference

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

19 October 2023

language of work or name

English

0 references

publication date

17 May 2011

0 references

0 references

0 references

0 references

664-78

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Structural studies of Ets-1/Pax5 complex formation on DNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Role of the TMPRSS2-ERG gene fusion in prostate cancer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

BRCA1 mutations and breast cancer in the general population: analyses in women before age 35 years and in women before age 45 years with first-degree family history

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Iniparib plus chemotherapy in metastatic triple-negative breast cancer

26 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Antibody-based detection of ERG rearrangement-positive prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Germline BRCA mutations denote a clinicopathologic subset of prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

An oncogenic role for ETV1 in melanoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Induced chromosomal proximity and gene fusions in prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Translocations in epithelial cancers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Recurrent gene fusions in prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

A causal role for ERG in neoplastic transformation of prostate epithelium.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Molecular concepts analysis links tumors, pathways, mechanisms, and drugs

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Integrative molecular concept modeling of prostate cancer progression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Transcription factors as targets for cancer therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

PARP inhibitors in cancer therapy: promise, progress, and puzzles

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

PARP and cancer--if it's broke, don't fix it.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Truncated ETV1, fused to novel tissue-specific genes, and full-length ETV1 in prostate cancer.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

DNA damage: ubiquitin marks the spot

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

TMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With Invasion

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3113473

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

29 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21575865

12 December 2020

inferred from PubMed ID database lookup

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21575865

12 December 2020

inferred from PubMed ID database lookup

BRCA1 Mutations and Breast Cancer in the General Population

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CCR.2011.04.010

7 January 2021

inferred from DOI database lookup

Functional genomic screens identify CINP as a genome maintenance protein

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.CCR.2011.04.010

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1016/J.CCR.2011.04.010

1 reference

release_4fcscglabjhdtc5sl43vl7jbg4

Fatcat ID

0 references

1 reference

1 reference

1 reference