Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection (Q38144256)

29 August 2017

title

Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection (English)

1 reference

29 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Michael Freeley

1 reference

29 August 2017

Aideen Long

series ordinal

1 reference

29 August 2017

language of work or name

English

0 references

publication date

1 October 2013

1 reference

29 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

455

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

133-147

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

Current prospects for RNA interference-based therapies

31 May 2020

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High-level transgene expression in primary human T lymphocytes and adult bone marrow CD34+ cells via electroporation-mediated gene delivery

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Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein

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RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice

21 January 2018

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Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

21 January 2018

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Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research

21 January 2018

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Small interfering RNA-mediated gene silencing in T lymphocytes

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High-throughput RNAi screening in vitro: from cell lines to primary cells.

21 January 2018

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Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation

21 January 2018

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Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes: roles of canonical and non-canonical NF-κB signalling

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New non-viral method for gene transfer into primary cells.

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Effective gene suppression using small interfering RNA in hard-to-transfect human T cells

21 January 2018

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Enrichment of nucleofected primary human CD4+ T cells: a novel and efficient method for studying gene function and role in human primary T helper cell differentiation.

21 January 2018

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Amplification of RNAi--targeting HLA mRNAs

21 January 2018

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Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

21 January 2018

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SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation

21 January 2018

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Modulation of HIV-1 replication by RNA interference

21 January 2018

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Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma

21 January 2018

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RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes

21 January 2018

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siRNA stabilization prolongs gene knockdown in primary T lymphocytes.

21 January 2018

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A2A adenosine receptor protects tumors from antitumor T cells.

21 January 2018

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Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model

21 January 2018

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PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.

21 January 2018

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RNAi screening: tips and techniques

21 January 2018

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HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway

21 January 2018

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Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene

21 January 2018

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WFDC1 expression identifies memory CD4 T- lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions

21 January 2018

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miR-146a controls the resolution of T cell responses in mice

21 January 2018

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21 January 2018

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Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo

21 January 2018

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21 January 2018

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Gammaretroviral vectors: biology, technology and application

21 January 2018

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Lentiviral vectors: basic to translational

21 January 2018

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Short hairpin RNA-mediated gene silencing

21 January 2018

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Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

21 January 2018

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Interaction between GATA-3 and the transcriptional coregulator Pias1 is important for the regulation of Th2 immune responses

21 January 2018

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Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling

21 January 2018

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Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506)

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR.

21 January 2018

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Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

21 January 2018

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Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Of Mice, Not Men: No Evidence for Graft-versus-Host Disease in Humans Receiving T-Cell Receptor–Transduced Autologous T Cells

21 January 2018

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Advances in the field of lentivector-based transduction of T and B lymphocytes for gene therapy

21 January 2018

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Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

21 January 2018

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

21 January 2018

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Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

21 January 2018

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Resistance of mature T cells to oncogene transformation

21 January 2018

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Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

21 January 2018

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

21 January 2018

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Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells.

21 January 2018

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High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion

21 January 2018

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Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

21 January 2018

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Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer

21 January 2018

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Lipid phosphatases identified by screening a mouse phosphatase shRNA library regulate T-cell differentiation and protein kinase B AKT signaling.

21 January 2018

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Dysfunctional memory CD8+ T cells after priming in the absence of the cell cycle regulator E2F4.

21 January 2018

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Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference

21 January 2018

1 reference

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Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells

21 January 2018

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MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

21 January 2018

1 reference

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Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity

21 January 2018

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Lentiviral delivery of short hairpin RNAs

21 January 2018

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Molecular strategies to design an escape-proof antiviral therapy

21 January 2018

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Creating genetic resistance to HIV.

21 January 2018

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

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Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

21 January 2018

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21 January 2018

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Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA.

21 January 2018

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Enhanced survival of lung tissue-resident memory CD8⁺ T cells during infection with influenza virus due to selective expression of IFITM3.

21 January 2018

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Transient proteasome inhibition as a strategy to enhance lentiviral transduction of hematopoietic CD34(+) cells and T lymphocytes: implications for the use of low viral doses and large-size vectors.

21 January 2018

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Stable transduction of quiescent T cells without induction of cycle progression by a novel lentiviral vector pseudotyped with measles virus glycoproteins.

21 January 2018

1 reference

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The CXCR4-tropic human immunodeficiency virus envelope promotes more-efficient gene delivery to resting CD4+ T cells than the vesicular stomatitis virus glycoprotein G envelope

21 January 2018

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Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness.

21 January 2018

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Cell type-specific targeting with surface-engineered lentiviral vectors co-displaying OKT3 antibody and fusogenic molecule

21 January 2018

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Targeting lentiviral vectors to specific cell types in vivo

21 January 2018

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Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

21 January 2018

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siRNA delivery using peptide transduction domains

21 January 2018

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Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Leukemia-specific siRNA delivery by immunonanoplexes consisting of anti-JL1 minibody conjugated to oligo-9 Arg-peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

The insider's guide to leukocyte integrin signalling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Signatures of human regulatory T cells: an encounter with old friends and new players

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

PKC-θ function at the immunological synapse: prospects for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Systemic siRNA delivery to leukocyte-implicated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Monoclonal antibodies and progressive multifocal leukoencephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

A review of nanocarriers for the delivery of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Dynamic regulatory network controlling TH17 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Characterization of carbosilane dendrimers as effective carriers of siRNA to HIV-infected lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

siRNA nanocarriers based on methacrylic acid copolymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Current progress of RNA aptamer-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Aptamer mediated siRNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Inhibition of HIV-1 protease expression in T cells owing to DNA aptamer-mediated specific delivery of siRNA.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

A new nucleic acid-based agent inhibits cytotoxic T lymphocyte-mediated immune disorders

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130950

PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Nanoparticulate nonviral agent for the effective delivery of pDNA and siRNA to differentiated cells and primary human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Targeted delivery of siRNA to cell death proteins in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Lymphocyte cell-cycle inhibition by HLA-G is mediated by phosphatase SHP-2 and acts on the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

CTLs respond with activation and granule secretion when serving as targets for T-cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Interferon-inducible gene 202b controls CD8(+) T cell-mediated suppression in anti-DNA Ig peptide-treated (NZB × NZW) F1 lupus mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Inhibition of T-cell activation by syndecan-4 is mediated by CD148 through protein tyrosine phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Protective HIV-specific CD8+ T cells evade Treg cell suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Tc17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Knockdown of interleukin-2 by shRNA-mediated RNA interference prolongs liver allograft survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Suppressors of cytokine signaling inhibit effector T cell responses during Mycobacterium tuberculosis Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Characterization of in vivo Dlg1 deletion on T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Modeling CTLA4-linked autoimmunity with RNA interference in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

RNA-based therapeutics: current progress and future prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

Antiviral strategies combining antiretroviral drugs with RNAi-mediated attack on HIV-1 and cellular co-factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130950

21 January 2018

Identifiers

DOI

10.1042/BJ20130950

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24070422%20AND%20SRC:MED&resulttype=core&format=json