Chronic lymphocytic leukaemia--the role of the microenvironment pathogenesis and therapy (Q38101683)

28 August 2017

title

Chronic lymphocytic leukaemia--the role of the microenvironment pathogenesis and therapy (English)

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28 August 2017

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Manuel Rodriguez-Justo

object named as

Manuel Rodriguez-Justo

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Alan D Ramsay

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28 August 2017

language of work or name

English

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publication date

25 April 2013

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British Journal of Haematology

28 August 2017

published in

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28 August 2017

volume

162

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28 August 2017

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28 August 2017

page(s)

15-24

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B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol

28 August 2017

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Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): From understanding the basics towards therapeutic targeting

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Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape

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Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B cells

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Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

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TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia

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Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

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Role of the extracellular and transmembrane domain of Ig-alpha/beta in assembly of the B cell antigen receptor (BCR).

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First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

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Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

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Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

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The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

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Treatment of chronic lymphocytic leukemia requires targeting of the protective lymph node environment with novel therapeutic approaches.

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The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia

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Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

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Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis

21 January 2018

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

21 January 2018

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The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

21 January 2018

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The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo

21 January 2018

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

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Contribution of alpha6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with alpha4 integrins

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Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia.

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The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

21 January 2018

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Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

21 January 2018

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Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia

21 January 2018

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A possible role for oxidation stress in lymphoid leukaemias and therapeutic failure

21 January 2018

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HS1 has a central role in the trafficking and homing of leukemic B cells

21 January 2018

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Notch, a unifying target in T-cell acute lymphoblastic leukemia?

21 January 2018

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Signaling pathways activated by the B-cell receptor in chronic lymphocytic leukemia.

21 January 2018

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Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways?

21 January 2018

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The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival

21 January 2018

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Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

21 January 2018

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RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans

21 January 2018

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Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia

21 January 2018

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Identification of the TCL1 gene involved in T-cell malignancies

21 January 2018

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Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease.

21 January 2018

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Disease burden of chronic lymphocytic leukaemia within the European Union

21 January 2018

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p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

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Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia

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21 January 2018

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Enzastaurin hydrochloride for lymphoma: reassessing the results of clinical trials in light of recent advances in the biology of B-cell malignancies

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21 January 2018

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Chronic lymphocytic leukemia and treatment resistance in cancer: the role of the p53 pathway

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Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

21 January 2018

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Mechanism of antigen-driven selection in germinal centres

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21 January 2018

Identifiers

DOI

10.1111/BJH.12344

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28 August 2017

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