Regulation of B-cell fate by antigen-receptor signals (Q35014068)

5 August 2017

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title

Regulation of B-cell fate by antigen-receptor signals (English)

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5 August 2017

Edward A Clark

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Hiroaki Niiro

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5 August 2017

publication date

1 December 2002

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Nature Reviews Immunology

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

945-956

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

5 August 2017

cites work

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

31 March 2020

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Deletion of immunoglobulin beta in developing B cells leads to cell death

31 March 2020

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B cell development pathways

31 March 2020

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Genetic analysis of B cell antigen receptor signaling

31 March 2020

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Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

31 March 2020

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The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation.

31 March 2020

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Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase.

31 March 2020

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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

31 March 2020

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

31 March 2020

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

31 March 2020

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

31 March 2020

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Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

31 March 2020

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Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

31 March 2020

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

31 March 2020

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Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway

31 March 2020

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BLNK: a central linker protein in B cell activation

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BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

31 March 2020

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Requirement for B cell linker protein (BLNK) in B cell development

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B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

31 March 2020

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The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

31 March 2020

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Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

31 March 2020

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

31 March 2020

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31 March 2020

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A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase

31 March 2020

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The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival

31 March 2020

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CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A

31 March 2020

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CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

31 March 2020

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Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

31 March 2020

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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux

31 March 2020

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CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1

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Monomeric and oligomeric complexes of the B cell antigen receptor

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Lipid rafts and B-cell activation

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Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex

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Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis

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Membrane compartmentation is required for efficient T cell activation.

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Xid-like phenotypes: a B cell signalosome takes shape

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Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes

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A requirement for lipid rafts in B cell receptor induced Ca(2+) flux

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Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation.

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Tyrosine phosphorylation is required for ligand-induced internalization of the antigen receptor on B lymphocytes

31 March 2020

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Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization

31 March 2020

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

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B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

31 March 2020

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

31 March 2020

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

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Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

31 March 2020

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Signaling networks that link cell proliferation and cell fate

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Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor.

31 March 2020

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Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen

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Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes

31 March 2020

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MEK kinase activity is not necessary for Raf-1 function

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

31 March 2020

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

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Control of apoptosis by Rel/NF-kappaB transcription factors

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IkappaB kinase alpha is essential for mature B cell development and function

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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IkappaB kinase signaling is essential for maintenance of mature B cells

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Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

31 March 2020

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Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

31 March 2020

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The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes

31 March 2020

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Multiple pathways control protein kinase C phosphorylation

31 March 2020

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Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta

31 March 2020

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Protein kinase Cδ controls self-antigen-induced B-cell tolerance

31 March 2020

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Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

31 March 2020

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Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

31 March 2020

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PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

31 March 2020

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The NF-kappa B and I kappa B proteins: new discoveries and insights

31 March 2020

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An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis

31 March 2020

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B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

31 March 2020

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Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

31 March 2020

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Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

31 March 2020

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NF-kappaB and cell-cycle regulation: the cyclin connection

31 March 2020

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Vav is required for cyclin D2 induction and proliferation of mouse B lymphocytes activated via the antigen Receptor.

31 March 2020

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Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

31 March 2020

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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

31 March 2020

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Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells

31 March 2020

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Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter

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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

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Transitional B cells are the target of negative selection in the B cell compartment

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Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development

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Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation

31 March 2020

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CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals.

31 March 2020

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Visualization of specific B and T lymphocyte interactions in the lymph node

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Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

31 March 2020

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B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta

31 March 2020

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Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool

31 March 2020

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Role of Syk in B-cell development and antigen-receptor signaling

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BAFF mediates survival of peripheral immature B lymphocytes

31 March 2020

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An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

31 March 2020

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BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

31 March 2020

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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

31 March 2020

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Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators.

31 March 2020

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Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response

31 March 2020

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

31 March 2020

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BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2

31 March 2020

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Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI

31 March 2020

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Requirement for NF-kappaB in osteoclast and B-cell development

31 March 2020

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Origins and functions of B-1 cells with notes on the role of CD5

31 March 2020

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31 March 2020

Marginal-zone B cells

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Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

31 March 2020

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The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2.

31 March 2020

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Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

31 March 2020

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Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk

31 March 2020

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The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21

31 March 2020

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

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Essential immunoregulatory role for BCAP in B cell development and function

31 March 2020

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BAFF is a survival and maturation factor for mouse B cells

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Positive selection of natural autoreactive B cells

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Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow

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Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

31 March 2020

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Cutting edge commentary: two B-1 or not to be one

31 March 2020

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Peritoneal CD5+ B-1 cells have signaling properties similar to tolerant B cells

31 March 2020

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Immunodeficiency in protein kinase cbeta-deficient mice

31 March 2020

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The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

31 March 2020

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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

31 March 2020

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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

31 March 2020

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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

31 March 2020

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Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice

31 March 2020

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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

31 March 2020

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Aiolos regulates B cell activation and maturation to effector state

31 March 2020

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Reduction of marginal zone B cells in CD22-deficient mice

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Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

31 March 2020

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The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways

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Nuclear factor kappa B is required for the development of marginal zone B lymphocytes

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Rapid leukocyte integrin activation by chemokines

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Integrin-mediated long-term B cell retention in the splenic marginal zone.

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Constitutive nuclear factor-kappaB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins

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Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.

31 March 2020

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Cutting edge: differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains.

31 March 2020

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Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells

31 March 2020

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Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

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Cd19-dependent activation of Akt kinase in B-lymphocytes

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CD22 regulates thymus-independent responses and the lifespan of B cells.

31 March 2020

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BCR mediated signal transduction in immature and mature B cells

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31 March 2020

Identifiers

DOI

10.1038/NRI955

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Dimensions Publication ID

5 August 2017

1038577520

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