The immunology of acute stroke (Q38016069)

27 August 2017

title

The immunology of acute stroke (English)

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27 August 2017

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Xabier Urra

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Andreas Meisel

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Diederik van de Beek

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Roland Veltkamp

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27 August 2017

Ángel Chamorro

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27 August 2017

Anna M Planas

series ordinal

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27 August 2017

language of work or name

English

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publication date

5 June 2012

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27 August 2017

published in

Nature Reviews Neurology

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27 August 2017

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27 August 2017

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27 August 2017

page(s)

401-410

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The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

27 August 2017

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

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T-cell apoptosis in inflammatory brain lesions: destruction of T cells does not depend on antigen recognition

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Neuronal regulation of immune responses in the central nervous system

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Astrocytes are active players in cerebral innate immunity

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A revised view of the central nervous system microenvironment and major histocompatibility complex class II antigen presentation

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Elaborate interactions between the immune and nervous systems

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What is immune privilege (not)?

21 January 2018

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Sterile inflammation: sensing and reacting to damage

21 January 2018

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Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke.

21 January 2018

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Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease

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Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression.

21 January 2018

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Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke

21 January 2018

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Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox

21 January 2018

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Toll-like receptors: balancing host resistance with immune tolerance

21 January 2018

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The immunology of stroke: from mechanisms to translation

21 January 2018

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High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

21 January 2018

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Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia

21 January 2018

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Uric acid promotes an acute inflammatory response to sterile cell death in mice

21 January 2018

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Heat shock proteins as endogenous adjuvants in sterile and septic inflammation

21 January 2018

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Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.

21 January 2018

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RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

21 January 2018

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Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

21 January 2018

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

mRNA is an endogenous ligand for Toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

How dying cells alert the immune system to danger

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Pattern recognition receptors and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Monocyte subtypes predict clinical course and prognosis in human stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Development of monocytes, macrophages, and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Monocytes are major players in the prognosis and risk of infection after acute stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Infarct volume is a major determiner of post-stroke immune cell function and susceptibility to infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Alterations in plasma complement levels after human ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Complement activation in the central nervous system following blood-brain barrier damage in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Role of T lymphocytes and interferon-gamma in ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Fingolimod provides long-term protection in rodent models of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Myelin antigen reactive T cells in cerebrovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Antibodies to brain antigens following stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Brain-derived antigens in lymphoid tissue of patients with acute stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Sensitization and tolerization to brain antigens in stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Sensitization to brain antigens after stroke is augmented by lipopolysaccharide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Autoimmune responses to the brain after stroke are associated with worse outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Recombinant T cell receptor ligand treats experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

How inflammation modulates central nervous system vessel activation and provides targets for intervention—a personal perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Long term immunologic consequences of experimental stroke and mucosal tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Regulatory T cells and immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Lymphocyte targeting of the brain in adoptive transfer cryolesion-EAE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Post-stroke infection: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Risk factors, inpatient care, and outcomes of pneumonia after ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The cost of pneumonia after acute stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The effect of pneumonia on mortality among patients hospitalized for acute stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Preventive antibiotics for infections in acute stroke: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Dysphagia after stroke: incidence, diagnosis, and pulmonary complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Risk factors for chest infection in acute stroke: a prospective cohort study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Urinary tract infections complicating stroke: mechanisms, consequences, and possible solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Urinary tract infection after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Neural-immune interactions: an integrative view of the bidirectional relationship between the brain and immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Lateralization of T-lymphocyte responses in patients with stroke. Effect of sympathetic dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in Wistar rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Swallowing disturbance pattern relates to brain lesion location in acute stroke patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The impact of lesion location and lesion size on poststroke infection frequency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The spectrum of systemic immune alterations after murine focal ischemia: immunodepression versus immunomodulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Central nervous system injury-induced immune deficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Functional innervation of hepatic iNKT cells is immunosuppressive following stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Immunology. Neuroimmune communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Reduced efficacy of circulating costimulatory cells after focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Functional status of peripheral blood T-cells in ischemic stroke patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Catecholamines, infection, and death in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Mechanisms of brain-mediated systemic anti-inflammatory syndrome causing immunodepression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Pathophysiological changes of the gastrointestinal tract in ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

The Early Systemic Prophylaxis of Infection After Stroke study: a randomized clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Minocycline treatment in acute stroke: an open-label, evaluator-blinded study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Effects of prophylactic antibiotic therapy with mezlocillin plus sulbactam on the incidence and height of fever after severe acute ischemic stroke: the Mannheim infection in stroke study (MISS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Preventive antibiotics in stroke study: rationale and protocol for a randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Interleukin-6 and interleukin-1 receptor antagonist in acute stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Proinflammatory cytokines and early neurological worsening in ischemic stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Uric Acid Levels Are Relevant in Patients With Stroke Treated With Thrombolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

TLR-dependent T cell activation in autoimmunity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Antibiotic therapy for preventing infections in patients with acute stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Influence of stroke localization on autonomic activation, immunodepression, and post-stroke infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Acute stroke predisposes to oral gram-negative bacilli -- a cause of aspiration pneumonia?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Urinary tract infection and bacteriurua in stroke patients: frequencies, pathogen microorganisms, and risk factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2012.98

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22664787

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRNEUROL.2012.98

1 reference

Dimensions Publication ID

27 August 2017

1027989522

0 references

1 reference