Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials. (Q37975527)

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20 January 2020

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13 November 2020

18 July 2021

Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials (English)

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20 January 2020

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13 November 2020

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20 January 2020

Arnab K Chatterjee

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20 January 2020

publication date

1 January 2012

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Current Topics in Medicinal Chemistry

20 January 2020

published in

5 references

22 June 2019

25 June 2019

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20 January 2020

issue

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page(s)

473-483

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Creative Commons Attribution 2.5 Generic

20 January 2020

4 references

22 June 2019

25 June 2019

13 November 2020

Target identification and validation of novel antimalarials

18 July 2021

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1 reference

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Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

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A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

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Spiroindolones, a potent compound class for the treatment of malaria

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Thousands of chemical starting points for antimalarial lead identification

6 September 2017

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Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

6 September 2017

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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

6 September 2017

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6 September 2017

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6 September 2017

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

6 September 2017

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The past, present and future of antifolates in the treatment of Plasmodium falciparum infection

6 September 2017

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An efficient rapid system for profiling the cellular activities of molecular libraries.

6 September 2017

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Predictive in silico modeling for hERG channel blockers

6 September 2017

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6 September 2017

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6 September 2017

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PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

6 September 2017

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Thermodynamics of ligand binding and efficiency

6 September 2017

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6 September 2017

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Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

6 September 2017

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14 September 2017

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Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials

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NADPH-dependent formation of polar and nonpolar estrogen metabolites following incubations of 17 beta-estradiol with human liver microsomes

1 September 2018

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10.2174/156802612799362977

1 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22242845%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22242845%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

22242845

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22242845%20AND%20SRC:MED&resulttype=core&format=json