Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer (Q37930972)

25 August 2017

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title

Therapeutic potential of targeting sphingosine kinase 1 in prostate cancer (English)

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25 August 2017

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Dmitri Pchejetski

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25 August 2017

Torsten Böhler

series ordinal

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25 August 2017

Justin Stebbing

series ordinal

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25 August 2017

Jonathan Waxman

series ordinal

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25 August 2017

language of work or name

English

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publication date

13 September 2011

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25 August 2017

published in

Nature Reviews Urology

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

569-678

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Molecular alterations in prostate cancer

25 August 2017

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Extracellular and Intracellular Actions of Sphingosine-1-Phosphate

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Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells

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Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

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An oncogenic role of sphingosine kinase

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Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

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Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

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Overexpression of sphingosine kinase 1 is an oncogenic event in erythroleukemic progression

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Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting sphingosine kinase-1.

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Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF-κB Pathway in Human Non–Small Cell Lung Cancer

21 January 2018

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Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

21 January 2018

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Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators

21 January 2018

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Sphingosine kinase 1 protein and mRNA are overexpressed in non-Hodgkin lymphomas and are attractive targets for novel pharmacological interventions

21 January 2018

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Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).

21 January 2018

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Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

21 January 2018

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High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation

21 January 2018

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Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal

21 January 2018

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Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase-dependent directional migration of leukocytes in response to phorbol ester

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Signaling and biological actions of sphingosine 1-phosphate

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

VEGF receptor expression and signaling in human bladder tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Early induction of apoptosis in androgen-independent prostate cancer cell line by FTY720 requires caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Anticarcinogenic effect of FTY720 in human prostate carcinoma DU145 cells: modulation of mitogenic signaling, FAK, cell-cycle entry and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingo-guanidines and their use as inhibitors of sphingosine kinase (WO2010078247)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720 (fingolimod) in renal transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Immunosuppressive therapy and post-transplant malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720 versus mycophenolate mofetil in de novo renal transplantation: six-month results of a double-blind study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

FTY720, a novel immunomodulator in de novo kidney transplant patients: pharmacokinetics and exposure-response relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The heart rate decrease caused by acute FTY720 administration is mediated by the G protein-gated potassium channel I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Finding a way out: lymphocyte egress from lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Essential role for sphingosine kinases in neural and vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Delta-catenin/NPRAP (neural plakophilin-related armadillo repeat protein) interacts with and activates sphingosine kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The mechanism of membrane targeting of human sphingosine kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Coordinate regulation of sphingosine kinase and actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Identification of PECAM-1 association with sphingosine kinase 1 and its regulation by agonist-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Aminoacylase 1 is a sphingosine kinase 1-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Deactivation of sphingosine kinase 1 by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

High Expression of Sphingosine 1-Phosphate Receptors, S1P1 and S1P3, Sphingosine Kinase 1, and Extracellular Signal-Regulated Kinase-1/2 Is Associated with Development of Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The expression of sphingosine kinase-1 in head and neck carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Biologically active sphingolipids in cancer pathogenesis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

An update on sphingosine-1-phosphate and other sphingolipid mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Principles of bioactive lipid signalling: lessons from sphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase activation mediates ischemic preconditioning in murine heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Tumor necrosis factor-alpha-stimulated cell proliferation is mediated through sphingosine kinase-dependent Akt activation and cyclin D expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

SphK1 regulates proinflammatory responses associated with endotoxin and polymicrobial sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Role of sphingosine kinase 2 in cell migration toward epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Ethnic sensitivity study of fingolimod in white and Asian subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRUROL.2011.117

Regulatory T cells in tumor immunity

31 March 2020

1 reference

12 December 2020

First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients

1 reference

12 December 2020

Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells

1 reference

12 December 2020

Regulation of sphingosine kinase and sphingolipid signaling.

1 reference

12 December 2020

Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.

1 reference

12 December 2020

Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.

1 reference

12 December 2020

Discovery and evaluation of inhibitors of human sphingosine kinase

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRUROL.2011.117

1 reference

25 August 2017

1 reference