Lifting the lid on GPCRs: the role of extracellular loops (Q37921853)

25 August 2017

1 reference

title

Lifting the lid on GPCRs: the role of extracellular loops (English)

1 reference

G protein-coupled receptor

25 August 2017

0 references

1 reference

25 August 2017

D Wootten

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M Wheatley

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J Simms

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M T Conner

1 reference

25 August 2017

R Kendrick

series ordinal

1 reference

25 August 2017

R T Logan

series ordinal

1 reference

25 August 2017

J Barwell

series ordinal

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25 August 2017

language of work or name

English

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publication date

1 March 2012

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British Journal of Pharmacology

25 August 2017

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25 August 2017

165

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25 August 2017

1 reference

25 August 2017

1688-1703

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

25 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Structure of the human histamine H1 receptor complex with doxepin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Successful prediction of the intra- and extracellular loops of four G-protein-coupled receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Structure of an agonist-bound human A2A adenosine receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Crystal structure of metarhodopsin II

6 September 2017

1 reference

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The structural basis of agonist-induced activation in constitutively active rhodopsin

6 September 2017

1 reference

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

6 September 2017

1 reference

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Structure and function of an irreversible agonist-β(2) adrenoceptor complex

6 September 2017

1 reference

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

6 September 2017

1 reference

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

6 September 2017

1 reference

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Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Highly conserved tyrosine stabilizes the active state of rhodopsin

6 September 2017

1 reference

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

6 September 2017

1 reference

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Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints

6 September 2017

1 reference

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Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

6 September 2017

1 reference

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Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region

6 September 2017

1 reference

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Regulation of signal transduction by calcitonin gene-related peptide receptors

6 September 2017

1 reference

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Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.

6 September 2017

1 reference

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V2R mutations and nephrogenic diabetes insipidus.

6 September 2017

1 reference

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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

6 September 2017

1 reference

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Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor

6 September 2017

1 reference

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Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

6 September 2017

1 reference

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Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.

6 September 2017

1 reference

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A G protein-coupled receptor at work: the rhodopsin model.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

6 September 2017

1 reference

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Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

6 September 2017

1 reference

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Passing the baton in class B GPCRs: peptide hormone activation via helix induction?

6 September 2017

1 reference

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Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.

6 September 2017

1 reference

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Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

6 September 2017

1 reference

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

6 September 2017

1 reference

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Crystal structure of opsin in its G-protein-interacting conformation

6 September 2017

1 reference

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Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

6 September 2017

1 reference

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Structure of a beta1-adrenergic G-protein-coupled receptor

6 September 2017

1 reference

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Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition.

6 September 2017

1 reference

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

6 September 2017

1 reference

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

6 September 2017

1 reference

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Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding

6 September 2017

1 reference

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Mapping peptide hormone-receptor interactions using a disulfide-trapping approach

6 September 2017

1 reference

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Structural diversity of G protein-coupled receptors and significance for drug discovery

6 September 2017

1 reference

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Conformational changes in the parathyroid hormone receptor associated with activation by agonist

6 September 2017

1 reference

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Heterotrimeric G protein activation by G-protein-coupled receptors

6 September 2017

1 reference

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

6 September 2017

1 reference

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

6 September 2017

1 reference

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Crystal Structure of a Thermally Stable Rhodopsin Mutant

6 September 2017

1 reference

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Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

6 September 2017

1 reference

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Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

6 September 2017

1 reference

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Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression

6 September 2017

1 reference

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Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

6 September 2017

1 reference

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Novel procedure for modeling ligand/receptor induced fit effects.

6 September 2017

1 reference

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

6 September 2017

1 reference

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G-protein-coupled receptors: past, present and future.

6 September 2017

1 reference

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Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains

6 September 2017

1 reference

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Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

6 September 2017

1 reference

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Structure of bovine rhodopsin in a trigonal crystal form.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Gonadotropin-releasing hormone receptors

6 September 2017

1 reference

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The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

6 September 2017

1 reference

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

6 September 2017

1 reference

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Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe

6 September 2017

1 reference

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Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus

6 September 2017

1 reference

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Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P. Photoaffinity labeling and modeling studies

6 September 2017

1 reference

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Identification of the glycosylation sites utilized on the V1a vasopressin receptor and assessment of their role in receptor signalling and expression

6 September 2017

1 reference

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Conformation of a peptide ligand bound to its G-protein coupled receptor

6 September 2017

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

6 September 2017

1 reference

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Expression and functional characterization of mutant human CXCR4 in insect cells: role of cysteinyl and negatively charged residues in ligand binding

6 September 2017

1 reference

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Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role.

6 September 2017

1 reference

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Structure of the integral membrane domain of the GLP1 receptor

6 September 2017

1 reference

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Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane

6 September 2017

1 reference

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Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state

6 September 2017

1 reference

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Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation

6 September 2017

1 reference

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Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding

6 September 2017

1 reference

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Structural insights into the role of the ACTH receptor cysteine residues on receptor function

14 September 2017

1 reference

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Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors

14 September 2017

1 reference

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Essential role for the second extracellular loop in C5a receptor activation

14 September 2017

1 reference

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Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Molecular characterization of the substance P*neurokinin-1 receptor complex: development of an experimentally based model.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Mutations of the second extracellular loop of the human lutropin receptor emphasize the importance of receptor activation and de-emphasize the importance of receptor phosphorylation in agonist-induced internalization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Chimeric strategies for the rational design of bioactive analogs of small peptide hormones

28 September 2017

1 reference

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Disulfide bridges in extracellular domains of angiotensin II receptor type IA

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.

28 September 2017

1 reference

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Loop modeling: Sampling, filtering, and scoring

23 June 2018

1 reference

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Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

23 June 2018

1 reference

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The arrangement of the transmembrane helices in the secretin receptor family of G‐protein‐coupled receptors

23 June 2018

1 reference

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Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Site-directed mutagenesis of beta-adrenergic receptors. Identification of conserved cysteine residues that independently affect ligand binding and receptor activation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Analysis of Disease-Linked Rhodopsin Mutations Based on Structure, Function, and Protein Stability Calculations

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The minor binding pocket: a major player in 7TM receptor activation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Role of the Cys18-Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The role of Glu181 in the photoactivation of rhodopsin

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The repertoire of G-protein-coupled receptors in fully sequenced genomes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Active peptidic mimics of the second intracellular loop of the V(1A) vasopressin receptor are structurally related to the second intracellular rhodopsin loop: a combined 1H NMR and biochemical study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

An opsin mutant with increased thermal stability

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Two mutations in extracellular loop 2 of the human GnRH receptor convert an antagonist to an agonist.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

NMR and modeling studies of a synthetic extracellular loop II of the kappa opioid receptor in a DPC micelle

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Solution structure of the second extracellular loop of human thromboxane A2 receptor

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Allosteric Modulation of G Protein–Coupled Receptors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implications

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3372823

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

3 December 2018

1 reference

12 December 2020

Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation

1 reference

12 December 2020

TSH Receptor Mutations and Thyroid Disease

1 reference

12 December 2020

The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines

1 reference

12 December 2020

Characterization of parathyroid hormone/receptor interactions: structure of the first extracellular loop

1 reference

12 December 2020

Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin

1 reference

12 December 2020

Class-B GPCR activation: is ligand helix-capping the key?

1 reference

12 December 2020

Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor

1 reference

12 December 2020

An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation

1 reference

12 December 2020

Incorporation of an additional glycosylation site enhances expression of functional human gonadotropin-releasing hormone receptor

1 reference

12 December 2020

Identification of critical extracellular loop residues involved in alpha 1-adrenergic receptor subtype-selective antagonist binding

1 reference

12 December 2020

Disulfide bridge engineering in the tachykinin NK1 receptor

1 reference

12 December 2020

Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling

1 reference

12 December 2020

The second extracellular loop: a damper for G protein-coupled receptors?

1 reference

12 December 2020

10.1111/J.1476-5381.2011.01629.X

Identifiers

DOI

1 reference

25 August 2017

1 reference

25 August 2017

PubMed publication ID

21864311

1 reference