The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection (Q37900925)

25 August 2017

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title

The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection (English)

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25 August 2017

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Enrique Lara-Pezzi

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Samuel Martin-Vilchez

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25 August 2017

Maria Trapero-Marugán

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25 August 2017

Ricardo Moreno-Otero

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25 August 2017

Paloma Sanz-Cameno

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25 August 2017

publication date

14 July 2011

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Reviews in Medical Virology

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

315-329

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Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B

25 August 2017

cites work

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Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat

21 January 2018

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Hepatitis B virus biology

21 January 2018

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Hepatitis B virus replication

21 January 2018

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The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesis

21 January 2018

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Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage

21 January 2018

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Hepatitis B virus X protein: structure, function and biology.

21 January 2018

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Expression and spectroscopic analysis of a mutant hepatitis B virus onco-protein HBx without cysteine residues

21 January 2018

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A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function

21 January 2018

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Three sites of the hepatitis B virus X protein cooperatively interact with cellular proteins

21 January 2018

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Intracellular localization of the hepatitis B virus HBx protein.

21 January 2018

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Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

21 January 2018

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Phosphorylation of purified recombinant hepatitis B virus-X protein by mitogen-activated protein kinase and protein kinase C in vitro

21 January 2018

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Expression of the hepatitis B virus X gene in mammalian cells

21 January 2018

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Stimulation of hepatitis B virus genome replication by HBx is linked to both nuclear and cytoplasmic HBx expression

21 January 2018

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Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice

21 January 2018

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Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway

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Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha

21 January 2018

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The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication

21 January 2018

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Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis

21 January 2018

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The enigmatic X gene of hepatitis B virus

21 January 2018

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Hepatitis B virus pX targets TFIIB in transcription coactivation

21 January 2018

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Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.

21 January 2018

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Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma

21 January 2018

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The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway

21 January 2018

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The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

21 January 2018

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HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions

21 January 2018

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Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors

21 January 2018

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The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription.

21 January 2018

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A pivotal role of cyclic AMP-responsive element binding protein in tumor progression

21 January 2018

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CREB/PKA sensitive signalling pathways activate and maintain expression levels of the hepatitis B virus pre-S2/S promoter.

21 January 2018

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Transactivation of human hepatitis B virus X protein, HBx, operates through a mechanism distinct from protein kinase C and okadaic acid activation pathways

21 January 2018

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Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes

21 January 2018

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Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes

21 January 2018

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Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

21 January 2018

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Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication.

21 January 2018

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Calcium signaling by HBx protein in hepatitis B virus DNA replication

21 January 2018

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Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication

21 January 2018

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Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential

21 January 2018

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Hepatitis B virus replication is associated with an HBx-dependent mitochondrion-regulated increase in cytosolic calcium levels

21 January 2018

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Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential

21 January 2018

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The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.

21 January 2018

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Molecular functions and biological roles of hepatitis B virus x protein

21 January 2018

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Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.

21 January 2018

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X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo

21 January 2018

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Enhancement of hepatitis B virus replication by its X protein in transgenic mice

21 January 2018

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HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice.

21 January 2018

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Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

21 January 2018

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Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls

21 January 2018

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Hepatitis B virus HBx protein activation of cyclin A-cyclin-dependent kinase 2 complexes and G1 transit via a Src kinase pathway

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Modulation of MAPK pathways and cell cycle by replicating hepatitis B virus: factors contributing to hepatocarcinogenesis

21 January 2018

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Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein

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Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3.

21 January 2018

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HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.

21 January 2018

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Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter.

21 January 2018

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Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression

21 January 2018

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The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication

21 January 2018

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Premature cell cycle entry induced by hepatitis B virus regulatory HBx protein during compensatory liver regeneration

21 January 2018

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HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis

21 January 2018

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HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint.

21 January 2018

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Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy

21 January 2018

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Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.

21 January 2018

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Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B.

21 January 2018

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Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1.

21 January 2018

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Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation

21 January 2018

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Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells

21 January 2018

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X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway

21 January 2018

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Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

21 January 2018

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

21 January 2018

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Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis

21 January 2018

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The hepatitis B virus HBx protein inhibits caspase 3 activity.

21 January 2018

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HBXIP functions as a cofactor of survivin in apoptosis suppression

21 January 2018

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Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells

21 January 2018

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Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress

21 January 2018

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Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners

21 January 2018

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HBx-induced reactive oxygen species activates hepatocellular carcinogenesisviadysregulation of PTEN/Akt pathway

21 January 2018

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Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

21 January 2018

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The hepatitis B virus X gene induces p53-mediated programmed cell death

21 January 2018

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Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis

21 January 2018

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p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

21 January 2018

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Expression of hepatitis B virus X protein does not alter the accumulation of spontaneous mutations in transgenic mice

21 January 2018

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The immune response during hepatitis B virus infection

21 January 2018

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The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes.

21 January 2018

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Hepatitis B virus X protein transactivates inducible nitric oxide synthase gene promoter through the proximal nuclear factor kappaB-binding site: evidence that cytoplasmic location of X protein is essential for gene transactivation

21 January 2018

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Cytokine regulation of liver injury and repair

21 January 2018

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Noncytolytic control of viral infections by the innate and adaptive immune response

21 January 2018

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The hepatitis B virus X protein disrupts innate immunity by downregulating mitochondrial antiviral signaling protein

21 January 2018

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Mechanisms of hepatic fibrogenesis

21 January 2018

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Liver fibrosis and chronic viral hepatitis.

21 January 2018

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The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells

21 January 2018

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Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets

21 January 2018

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Putative roles of hepatitis B x antigen in the pathogenesis of chronic liver disease

21 January 2018

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The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha

21 January 2018

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Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway

21 January 2018

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Role of the HBx oncoprotein in carbonic anhydrase 9 induction

21 January 2018

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Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells

21 January 2018

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New functions for the matrix metalloproteinases in cancer progression

21 January 2018

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Matrix metalloproteinases: regulators of the tumor microenvironment

21 January 2018

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Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally

21 January 2018

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Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3.

21 January 2018

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Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein

21 January 2018

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Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis

21 January 2018

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COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis

21 January 2018

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Characterization of HBV integrants in 14 hepatocellular carcinomas: association of truncated X gene and hepatocellular carcinogenesis.

21 January 2018

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In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

21 January 2018

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Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

21 January 2018

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Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells

21 January 2018

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Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249.

21 January 2018

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X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells

21 January 2018

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Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts

21 January 2018

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Mouse models in liver cancer research: A review of current literature

21 January 2018

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Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

21 January 2018

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HBx gene of hepatitis B virus induces liver cancer in transgenic mice

21 January 2018

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Virus replication and virion export in X-deficient hepatitis B virus transgenic mice

21 January 2018

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Hepatitis B virus X protein acts as a tumor promoter in development of diethylnitrosamine-induced preneoplastic lesions

21 January 2018

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Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein

21 January 2018

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The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

21 January 2018

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HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice.

21 January 2018

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Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/RMV.699

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25 August 2017

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