Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis (Q37904894)

25 August 2017

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title

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis (English)

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25 August 2017

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endoplasmic reticulum

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author name string

Charlene Supnet

series ordinal

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25 August 2017

Ilya Bezprozvanny

series ordinal

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25 August 2017

publication date

24 July 2011

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Science in China. Series C: Life Sciences

25 August 2017

published in

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25 August 2017

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25 August 2017

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25 August 2017

page(s)

744-751

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Forecasting the global burden of Alzheimer’s disease

25 August 2017

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Presenilin mutations in Alzheimer's disease

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Presenilin: RIP and beyond

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A nine-transmembrane domain topology for presenilin 1

21 January 2018

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Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

21 January 2018

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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The dysregulation of intracellular calcium in Alzheimer disease

21 January 2018

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

21 January 2018

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The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"?

21 January 2018

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Calcium signaling and amyloid toxicity in Alzheimer disease

21 January 2018

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

21 January 2018

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Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

21 January 2018

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Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview.

21 January 2018

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Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer's disease

21 January 2018

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Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.

21 January 2018

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Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

21 January 2018

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Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.

21 January 2018

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Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease

21 January 2018

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PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

21 January 2018

1 reference

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

21 January 2018

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Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

21 January 2018

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The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores

21 January 2018

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Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia.

21 January 2018

1 reference

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Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein

21 January 2018

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Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity.

21 January 2018

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Role of presenilins in neuronal calcium homeostasis

21 January 2018

1 reference

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NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice

21 January 2018

1 reference

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

21 January 2018

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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons

21 January 2018

1 reference

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Structural investigation of the C-terminal catalytic fragment of presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Mutagenesis mapping of the presenilin 1 calcium leak conductance pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Clinical phenotypic heterogeneity of Alzheimer's disease associated with mutations of the presenilin-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Correlating familial Alzheimer's disease gene mutations with clinical phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Variations in the neuropathology of familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Variant Alzheimer disease with spastic paraparesis: neuropathological phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Alzheimer's disease with spastic paresis and cotton wool type plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Pick bodies in a family with presenilin-1 Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Alzheimer's disease with spastic paraparesis and 'cotton wool' plaques: two pedigrees with PS-1 exon 9 deletions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

A novel mutation (G217D) in the Presenilin 1 gene ( PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Calcium homeostasis and modulation of synaptic plasticity in the aged brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

Calcium signaling and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-011-4201-Y

10.1007/S11427-011-4201-Y

21 January 2018

Identifiers

DOI

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25 August 2017

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