Treatment implications of the emerging molecular classification system for melanoma (Q37846978)

24 August 2017

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title

Treatment implications of the emerging molecular classification system for melanoma (English)

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24 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

targeted therapy

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

Emanuela Romano

1 reference

24 August 2017

Gary K. Schwartz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

Paul B. Chapman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

Jedd D. Wolchock

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

Richard D. Carvajal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21349766

25 November 2024

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21349766

25 November 2024

publication date

23 February 2011

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full work available at URL

24 August 2017

https://api.elsevier.com/content/article/PII:S1470204510702746?httpAccept=text/xml

1 reference

DOI

https://api.crossref.org/works/10.1016/S1470-2045(10)70274-6

https://api.elsevier.com/content/article/PII:S1470204510702746?httpAccept=text/plain

25 November 2024

1 reference

DOI

https://api.crossref.org/works/10.1016/S1470-2045(10)70274-6

Lancet Oncology Commission

25 November 2024

published in

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24 August 2017

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24 August 2017

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24 August 2017

page(s)

913-922

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24 August 2017

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7 January 2021

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7 January 2021

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7 January 2021

Distinct sets of genetic alterations in melanoma

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7 January 2021

Determinants of BRAF mutations in primary melanomas

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7 January 2021

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

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7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

BRAF mutation predicts sensitivity to MEK inhibition

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7 January 2021

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

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7 January 2021

Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

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7 January 2021

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7 January 2021

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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7 January 2021

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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7 January 2021

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7 January 2021

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

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7 January 2021

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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7 January 2021

CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

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7 January 2021

Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor

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7 January 2021

Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers

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7 January 2021

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

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7 January 2021

Differential sensitivity of human endometrial carcinoma cells with different PTEN expression to mitogen-activated protein kinase signaling inhibits and implications for therapy.

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7 January 2021

Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes

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7 January 2021

Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor

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7 January 2021

Somatic activation of KIT in distinct subtypes of melanoma

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7 January 2021

Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure

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7 January 2021

Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.

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7 January 2021

The role of KIT in the management of patients with gastrointestinal stromal tumors

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates

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7 January 2021

Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT

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7 January 2021

GAB2 amplifications refine molecular classification of melanoma

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7 January 2021

Gab2-mediated signaling promotes melanoma metastasis

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition

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7 January 2021

Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor

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7 January 2021

Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS.

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7 January 2021

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

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7 January 2021

Effects of G-protein mutations on skin color

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7 January 2021

Oncogenic mutations in GNAQ occur early in uveal melanoma

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7 January 2021

Mutations in GNA11 in uveal melanoma

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7 January 2021

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.

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7 January 2021

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

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7 January 2021

The histogenesis and biologic behavior of primary human malignant melanomas of the skin

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Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes

25 November 2024

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Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression

25 November 2024

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25 November 2024

Identifiers

DOI

1 reference

24 August 2017

1 reference