Advances in melanoma senescence and potential clinical application. (Q37818577)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

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title

Advances in melanoma senescence and potential clinical application (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Sandy Giuliano

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Mickaël Ohanna

series ordinal

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17 January 2020

language of work or name

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11 January 2011

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Pigment Cell & Melanoma Research

17 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

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17 January 2020

issue

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17 January 2020

page(s)

295-308

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

A two-step model for senescence triggered by a single critically short telomere

17 January 2020

cites work

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Living on a break: cellular senescence as a DNA-damage response

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

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Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis

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Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest

21 January 2018

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Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi

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Dual inactivation of RB and p53 pathways in RAS-induced melanomas

21 January 2018

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Role of epidermal growth factor receptor signaling in RAS-driven melanoma

21 January 2018

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DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'.

21 January 2018

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

21 January 2018

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Human melanocyte senescence and melanoma susceptibility genes

21 January 2018

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How to make a melanoma: what do we know of the primary clonal events?

21 January 2018

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Molecular regulation of melanocyte senescence

21 January 2018

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The signals and pathways activating cellular senescence

21 January 2018

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Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis

21 January 2018

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Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

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TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

21 January 2018

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The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes

21 January 2018

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Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

21 January 2018

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Fifteen-year quest for microphthalmia-associated transcription factor target genes

21 January 2018

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

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Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

21 January 2018

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Tumour biology: senescence in premalignant tumours

21 January 2018

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The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

21 January 2018

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The senescence-associated secretory phenotype: the dark side of tumor suppression

21 January 2018

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Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway.

21 January 2018

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Frequent mutations in the MITF pathway in melanoma

21 January 2018

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Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

21 January 2018

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Ectopic Tbx2 expression results in polyploidy and cisplatin resistance

21 January 2018

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Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Oncogenic Braf induces melanocyte senescence and melanoma in mice

21 January 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Frequent p16-independent inactivation of p14ARF in human melanoma

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Inflammatory networks during cellular senescence: causes and consequences

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

21 January 2018

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Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes

21 January 2018

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Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas.

21 January 2018

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Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

21 January 2018

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High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL

21 January 2018

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The Brn-2 transcription factor links activated BRAF to melanoma proliferation

21 January 2018

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Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

21 January 2018

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Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

21 January 2018

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ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

21 January 2018

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Melanomagenesis: overcoming the barrier of melanocyte senescence

21 January 2018

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p16INK4a-induced senescence is disabled by melanoma-associated mutations

21 January 2018

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The serial cultivation of human diploid cell strains

21 January 2018

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Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells.

21 January 2018

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p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

TBX3 and its splice variant TBX3 + exon 2a are functionally similar.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

21 January 2018

1 reference

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Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Expression of TBX2 promotes anchorage-independent growth and survival in the p53-negative SW13 adrenocortical carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

An oncogenic role for ETV1 in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress

21 January 2018

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Melanoma proliferation and chemoresistance controlled by the DEK oncogene

21 January 2018

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Senescence of activated stellate cells limits liver fibrosis

21 January 2018

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

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Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

21 January 2018

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

21 January 2018

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UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53.

21 January 2018

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

21 January 2018

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Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

21 January 2018

1 reference

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MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1

21 January 2018

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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

21 January 2018

1 reference

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Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

1 reference

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Temozolomide induces senescence but not apoptosis in human melanoma cells.

21 January 2018

1 reference

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

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BRAF(E600) in benign and malignant human tumours

21 January 2018

1 reference

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Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.

21 January 2018

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The SYK tyrosine kinase: a crucial player in diverse biological functions

21 January 2018

1 reference

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Epigenetic silencing of novel tumor suppressors in malignant melanoma

21 January 2018

1 reference

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A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

21 January 2018

1 reference

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Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

21 January 2018

1 reference

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Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study.

21 January 2018

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

21 January 2018

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T-box genes in development: from hydra to humans.

21 January 2018

1 reference

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

c-MYC: more than just a matter of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

BRAF and NRAS mutations in melanoma and melanocytic nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Stem cells, senescence, neosis and self-renewal in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Control of tumorigenesis and chemoresistance by the DEK oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Role of Src-specific phosphorylation site on focal adhesion kinase for senescence-associated apoptosis resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Apoptosis and melanoma chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

p16(Ink4a) in melanocyte senescence and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

T-targets: clues to understanding the functions of T-box proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Hydrogen peroxide sensing and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Hypermethylation of Syk gene in promoter region associated with oncogenesis and metastasis of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Multiple binding sites in the growth factor receptor Xmrk mediate binding to p59fyn, GRB2 and Shc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Role of HDAC1 in senescence, aging, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

HDAC family: What are the cancer relevant targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

DEK overexpression in uterine cervical cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

PI(3)king apart PTEN's role in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor-Negative Melanoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Intron Removal Requires Proofreading of U2AF/3' Splice Site Recognition by DEK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1755-148X.2010.00820.X

10.1111/J.1755-148X.2010.00820.X

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json

release_tyik35qumfejbfki5zfqgh6u5m

17 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tyik35qumfejbfki5zfqgh6u5m

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21143770%20AND%20SRC:MED&resulttype=core&format=json