Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. (Q53404327)

14 May 2018

title

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. (English)

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14 May 2018

M J van de Vijver

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14 May 2018

J J Jacobs

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14 May 2018

P Keblusek

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14 May 2018

E Robanus-Maandag

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14 May 2018

P Kristel

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14 May 2018

M Lingbeek

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14 May 2018

P M Nederlof

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14 May 2018

T van Welsem

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14 May 2018

E Y Koh

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14 May 2018

G Q Daley

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14 May 2018

M van Lohuizen

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14 May 2018

language of work or name

English

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publication date

1 November 2000

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14 May 2018

published in

Nature Genetics

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14 May 2018

volume

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14 May 2018

issue

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14 May 2018

page(s)

291-299

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14 May 2018

p53, the cellular gatekeeper for growth and division

cites work

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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7 January 2021

The INK4A/ARF locus and its two gene products

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7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

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7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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7 January 2021

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

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7 January 2021

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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7 January 2021

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

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7 January 2021

Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene

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7 January 2021

Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family

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7 January 2021

The T-box gene family

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7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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7 January 2021

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

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7 January 2021

p14ARF links the tumour suppressors RB and p53.

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7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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7 January 2021

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7 January 2021

Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome

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7 January 2021

Twist is a potential oncogene that inhibits apoptosis

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7 January 2021

Increased copy number at 17q22-q24 by CGH in breast cancer is due to high-level amplification of two separate regions

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7 January 2021

Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression

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7 January 2021

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

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7 January 2021

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

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7 January 2021

The hedgehog signalling pathway in tumorigenesis and development

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7 January 2021

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways

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7 January 2021

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

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7 January 2021

Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

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7 January 2021

p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer

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7 January 2021

Identifiers

DOI

10.1038/81583

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14 May 2018

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14 May 2018