Transporter Hypothesis of Drug-Resistant Epilepsy: Challenges for Pharmacogenetic Approaches (Q37806763)

23 August 2017

title

Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches (English)

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23 August 2017

Transporter Hypothesis of Drug-Resistant Epilepsy: Challenges for Pharmacogenetic Approaches (English)

1 reference

19 August 2024

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language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21047204

19 August 2024

publication date

1 October 2010

1 reference

full work available at URL

23 August 2017

http://www.futuremedicine.com/doi/abs/10.2217/pgs.10.126

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21047204

https://www.tandfonline.com/doi/pdf/10.2217/pgs.10.126

19 August 2024

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19 August 2024

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23 August 2017

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23 August 2017

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23 August 2017

page(s)

1427-1438

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Predictors of pharmacoresistant epilepsy

23 August 2017

cites work

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Drug resistance in brain diseases and the role of drug efflux transporters.

21 January 2018

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Molecular and cellular mechanisms of pharmacoresistance in epilepsy

21 January 2018

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Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema

21 January 2018

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Intrinsic severity as a determinant of antiepileptic drug refractoriness

21 January 2018

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MDR1 gene expression in brain of patients with medically intractable epilepsy

21 January 2018

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Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

21 January 2018

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Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats

21 January 2018

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Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats

21 January 2018

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Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

21 January 2018

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Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

21 January 2018

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Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats

21 January 2018

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Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats

21 January 2018

1 reference

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Effect of 21-day exposure of phenobarbital, carbamazepine and phenytoin on P-glycoprotein expression and activity in the rat brain

21 January 2018

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Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs

21 January 2018

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Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

21 January 2018

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Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

21 January 2018

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Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats

21 January 2018

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The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy

21 January 2018

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Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats

21 January 2018

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Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Several major antiepileptic drugs are substrates for human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine

21 January 2018

1 reference

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Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs

21 January 2018

1 reference

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Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Carbamazepine is not a substrate for P-glycoprotein

21 January 2018

1 reference

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Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations

21 January 2018

1 reference

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Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

21 January 2018

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Valproic acid uptake by bovine brain microvessel endothelial cells: role of active efflux transport.

21 January 2018

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Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy

21 January 2018

1 reference

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Expression and cellular distribution of multidrug resistance-related proteins in patients with focal cortical dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy

21 January 2018

1 reference

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Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy.

21 January 2018

1 reference

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Distribution and functional activity of P-glycoprotein and multidrug resistance-associated proteins in human brain microvascular endothelial cells in hippocampal sclerosis

21 January 2018

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Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy

21 January 2018

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Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain

21 January 2018

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Over-expression of P-glycoprotein in malformations of cortical development.

21 January 2018

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Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications

21 January 2018

1 reference

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Transient seizure-related MRI abnormalities

21 January 2018

1 reference

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Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

21 January 2018

1 reference

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Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.

21 January 2018

1 reference

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Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy

21 January 2018

1 reference

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Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy

21 January 2018

1 reference

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Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus

21 January 2018

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Addition of verapamil in the treatment of severe myoclonic epilepsy in infancy

21 January 2018

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Epilepsy pharmacogenetics

21 January 2018

1 reference

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Genetics of antiepileptic drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

ABC transporters in drug-refractory epilepsy: limited clinical significance of pharmacogenetics?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Therapeutic drug monitoring and clinical outcomes in epileptic Egyptian patients: a gene polymorphism perspective study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

ABCC2 haplotype is not associated with drug-resistant epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Conference Scene: The great debate: genome-wide association studies in pharmacogenetics research, good or bad?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.10.126

Limited P-glycoprotein mediated efflux for anti-epileptic drugs

21 January 2018

1 reference

Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy

19 August 2024

1 reference

The clinical impact of pharmacogenetics on the treatment of epilepsy

19 August 2024

1 reference

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

19 August 2024

1 reference

The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy

19 August 2024

1 reference

Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy

19 August 2024

1 reference

19 August 2024

Identifiers

DOI

10.2217/PGS.10.126

1 reference

release_fqsj4qiun5fjtmul64bxoxkxme

23 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fqsj4qiun5fjtmul64bxoxkxme

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference