Immune adjuvants in early life: targeting the innate immune system to overcome impaired adaptive response (Q37773306)

22 August 2017

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title

Immune adjuvants in early life: targeting the innate immune system to overcome impaired adaptive response (English)

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ORCID Public Data File 2021

22 August 2017

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author name string

Cyro Alves de Brito

series ordinal

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22 August 2017

Adriana Letícia Goldoni

series ordinal

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22 August 2017

Maria Notomi Sato

series ordinal

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22 August 2017

publication date

1 September 2009

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22 August 2017

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

883-895

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Mechanisms underlying adverse reactions to vaccines

22 August 2017

cites work

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Maternal immunization to modulate the development of allergic response and pathogen infections.

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T-cell function in newborn mice and humans

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21 January 2018

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Genetic immunization of neonates

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The challenges of vaccine responses in early life: selected examples

21 January 2018

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Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL.

21 January 2018

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Reduced ability of neonatal and early-life bone marrow stromal cells to support plasmablast survival.

21 January 2018

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Generation of adult-like antibody avidity profiles after early-life immunization with protein vaccines

21 January 2018

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Neonatal and early life vaccinology

21 January 2018

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Murine Neonatal Lymphocytes Show Rapid Early Cell Cycle Entry and Cell Division

21 January 2018

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21 January 2018

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Immune responsiveness in the neonatal period

21 January 2018

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Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

21 January 2018

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Cytokine networking in the placenta

21 January 2018

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A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy.

21 January 2018

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Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones

21 January 2018

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Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects.

21 January 2018

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The generation of Th memory in neonates versus adults: prolonged primary Th2 effector function and impaired development of Th1 memory effector function in murine neonates.

21 January 2018

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Induction of humoral and cellular immunity against influenza virus by immunization of newborn mice with a plasmid bearing a hemagglutinin gene

21 January 2018

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Murine neonatal CD4+ cells are poised for rapid Th2 effector-like function

21 January 2018

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IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2.

21 January 2018

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Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness

21 January 2018

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Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity

21 January 2018

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Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates.

21 January 2018

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Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection.

21 January 2018

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T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice

21 January 2018

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The influence of CD4+ CD25+ Foxp3+ regulatory T cells on the immune response to rotavirus infection

21 January 2018

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Regulatory T cells in immunologic self-tolerance and autoimmune disease

21 January 2018

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Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

21 January 2018

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Reduced cord blood immune effector-cell responsiveness mediated by CD4+ cells induced in utero as a consequence of placental Plasmodium falciparum infection

21 January 2018

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Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal

21 January 2018

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HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS.

21 January 2018

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21 January 2018

Neonatal T cell function

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Induction of protective CTL responses in newborn mice by a murine retrovirus

21 January 2018

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DNA immunization circumvents deficient induction of T helper type 1 and cytotoxic T lymphocyte responses in neonates and during early life

21 January 2018

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From tolerance to autoimmunity: is there a risk in early life vaccination?

21 January 2018

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The role of Toll-like receptors in the host response to viruses

21 January 2018

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21 January 2018

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Of mice and man: TLR11 (finally) finds profilin

21 January 2018

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Toll-like receptor signalling

21 January 2018

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Toll-like receptors and dendritic cells: for whom the bug tolls

21 January 2018

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Toll-like receptors and acquired immunity

21 January 2018

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Adjuvant activity of type I interferons

21 January 2018

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Targeting toll-like receptors for drug development: a summary of commercial approaches

21 January 2018

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Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities

21 January 2018

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Effects of endotoxin in the lungs of neonatal rats: age-dependent impairment of the inflammatory response.

21 January 2018

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Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood

21 January 2018

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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

21 January 2018

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

21 January 2018

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Hyper innate responses in neonates lead to increased morbidity and mortality after infection

21 January 2018

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CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus.

21 January 2018

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Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs.

21 January 2018

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Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells

21 January 2018

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Origins and functions of B-1 cells with notes on the role of CD5

21 January 2018

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

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In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases

21 January 2018

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Pharmacokinetics and safety of imiquimod 5% cream in the treatment of molluscum contagiosum in children

21 January 2018

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Pyogenic granuloma in children: treatment with topical imiquimod.

21 January 2018

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Topical imiquimod: a review of its use in the management of anogenital warts, actinic keratoses, basal cell carcinoma and other skin lesions

21 January 2018

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Treatment of human papilloma virus in a 6-month-old infant with imiquimod 5% cream

21 January 2018

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Involution of infantile haemangiomas after imiquimod 5% cream

21 January 2018

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Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses

21 January 2018

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Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa

21 January 2018

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Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells.

21 January 2018

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Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein

21 January 2018

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Toll-like receptor ligands directly promote activated CD4+ T cell survival

21 January 2018

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CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

21 January 2018

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Activated human neonatal CD8+ T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation.

21 January 2018

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The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.

21 January 2018

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Toll-like receptors in autoimmunity

21 January 2018

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Current concepts in immunology: the alternative pathway of complement--a system for host resistance to microbial infection.

21 January 2018

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Increased immunogenicity and induction of class switching by conjugation of complement C3d to pneumococcal serotype 14 capsular polysaccharide

21 January 2018

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Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity

21 January 2018

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Role of CR2 in the human adult and neonatal in vitro antibody response to type 4 pneumococcal polysaccharide

21 January 2018

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T cell-independent antigens type 2.

21 January 2018

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Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment

21 January 2018

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Reduction of pneumococcal nasopharyngeal carriage in early infancy after immunization with tetravalent pneumococcal vaccines conjugated to either tetanus toxoid or diphtheria toxoid

21 January 2018

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Streptococcus pneumoniae capsular polysaccharide-diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory.

21 January 2018

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C3d binding to the circumsporozoite protein carboxy-terminus deviates immunity against malaria.

21 January 2018

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Mouse CD1-specific NK1 T cells: development, specificity, and function

21 January 2018

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Neonatal invariant Valpha24+ NKT lymphocytes are activated memory cells.

21 January 2018

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Natural killer T cell activation inhibits hepatitis B virus replication in vivo.

21 January 2018

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Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells

21 January 2018

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A phase I-II study of alpha-galactosylceramide-pulsed IL-2/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer.

21 January 2018

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Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions

21 January 2018

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Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo

21 January 2018

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Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice

21 January 2018

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alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria

21 January 2018

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Hay fever, hygiene, and household size

21 January 2018

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The inverse association between tuberculin responses and atopic disorder.

21 January 2018

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Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

21 January 2018

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Early BCG vaccination and reduction in atopy in Guinea-Bissau

21 January 2018

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Inverse association between Mycobacterium tuberculosis infection and atopic rhinitis in children

21 January 2018

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Mycobacterium tuberculosis infection may protect against allergy in a tuberculosis endemic area.

21 January 2018

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Allergy, parasites, and the hygiene hypothesis

21 January 2018

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The effect of infections on susceptibility to autoimmune and allergic diseases

21 January 2018

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Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

21 January 2018

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Conclusions from the WHO multicenter study of serious infections in young infants

21 January 2018

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Molecular basis of improved immunogenicity in DNA vaccination mediated by a mannan based carrier

21 January 2018

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Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/IMT.09.38

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22 August 2017

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