Toll-like receptor signalling (Q24570126)

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English	Toll-like receptor signalling	scientific article

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scholarly article

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Europe PubMed Central

Toll-like receptor signalling (English)

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toll-like receptor

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1

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author name string

Kiyoshi Takeda

2

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language of work or name

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publication date

July 2004

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Nature Reviews Immunology

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4

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7

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499-511

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Innate immune recognition

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Innate immune sensing and its roots: the story of endotoxin

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll-like receptors and innate immunity

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll-like receptors: critical proteins linking innate and acquired immunity

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Leucine-rich repeats and pathogen recognition in Toll-like receptors.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Subcellular localization of Toll-like receptor 3 in human dendritic cells

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll-like receptors

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

MyD88, an adapter protein involved in interleukin-1 signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Pyogenic bacterial infections in humans with IRAK-4 deficiency

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Tumor necrosis factor receptor-associated factors (TRAFs)

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Distinct molecular mechanism for initiating TRAF6 signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Endotoxin-induced maturation of MyD88-deficient dendritic cells

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The Toll-IL-1 receptor adaptor family grows to five members.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IRF family of transcription factors as regulators of host defense

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

On the role of IRF in host defense

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Triggering the interferon antiviral response through an IKK-related pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Negative regulation of toll-like receptor-mediated signaling by Tollip

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The role of PI3K in immune cells

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

PI3K-mediated negative feedback regulation of IL-12 production in DCs

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

IRAK-M is a negative regulator of Toll-like receptor signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Negative regulation of cytokine signaling pathways

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

SOCS-1 participates in negative regulation of LPS responses

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Mycobacterial infection in MyD88-deficient mice

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting Edge: Protective Cell-Mediated Immunity to Listeria monocytogenes in the Absence of Myeloid Differentiation Factor 88

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

NODs: intracellular proteins involved in inflammation and apoptosis

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocation

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

1 reference

https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Murine retroviruses activate B cells via interaction with toll-like receptor 4

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The extra domain A of fibronectin activates Toll-like receptor 4.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Discrimination of bacterial lipoproteins by Toll-like receptor 6

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

A Toll-like receptor recognizes bacterial DNA

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

A toll-like receptor that prevents infection by uropathogenic bacteria

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https://api.crossref.org/works/10.1038%2FNRI1391

31 March 2020

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