Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases (Q37709379)

22 August 2017

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title

Targeting orphan nuclear receptor SHP in the treatment of metabolic diseases (English)

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22 August 2017

Mi-Kyung Kim

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22 August 2017

Dipanjan Chanda

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22 August 2017

In-Kyu Lee

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22 August 2017

Hueng-Sik Choi

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22 August 2017

Keun-Gyu Park

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22 August 2017

language of work or name

English

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publication date

1 April 2010

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Expert Opinion on Therapeutic Targets

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

453-466

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Banting lecture 1988. Role of insulin resistance in human disease

22 August 2017

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21 January 2018

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The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors

21 January 2018

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Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms

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Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation

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An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors

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Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers

21 January 2018

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

21 January 2018

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Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

21 January 2018

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Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

21 January 2018

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Synergistic activation of the human orphan nuclear receptor SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1

21 January 2018

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Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha

21 January 2018

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Estrogen receptor alpha regulates expression of the orphan receptor small heterodimer partner

21 January 2018

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Differential regulation of human and mouse orphan nuclear receptor small heterodimer partner promoter by sterol regulatory element binding protein-1.

21 January 2018

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Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway

21 January 2018

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Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1.

21 January 2018

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Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

The enzymes, regulation, and genetics of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

Bile acids: natural ligands for an orphan nuclear receptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

Redundant pathways for negative feedback regulation of bile acid production

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Resistance of SHP-null mice to bile acid-induced liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Hormonal regulation of hepatic gluconeogenesis and glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Glucagon and regulation of glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728221003652463

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

AMP-activated protein kinase: balancing the scales.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Identification of polymorphisms in the human SHP1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Endoplasmic reticulum stress and the development of diabetes: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Inflammation in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

A Nuclear Receptor Atlas: macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The orphan nuclear receptor SHP is involved in monocytic differentiation, and its expression is increased by c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Angiotensin II increases plasminogen activator inhibitor type 1 and tissue-type plasminogen activator messenger RNA in cultured rat aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Plasminogen activator inhibitor type 1 increases neointima formation in balloon-injured rat carotid arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Transcriptional control by the TGF-beta/Smad signaling system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Mechanisms of hepatic fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Specificity and versatility in tgf-beta signaling through Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Orphan nuclear receptor small heterodimer partner inhibits transforming growth factor-beta signaling by repressing SMAD3 transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The orphan nuclear receptor SHP attenuates renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Characterization of the interaction between androgen receptor and a new transcriptional inhibitor, SHP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Negative cross-talk between Nur77 and small heterodimer partner and its role in apoptotic cell death of hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003652463

10.1517/14728221003652463

21 January 2018

Identifiers

DOI

1 reference

release_72m7qeeudvcszntyzrrqbuivwe

22 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/72m7qeeudvcszntyzrrqbuivwe

mapped directly with Wikidata item

24 November 2022

based on heuristic

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