The role and therapeutic potential of monocytic cells in Alzheimer's disease. (Q37692374)

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18 January 2020

review article

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title

The role and therapeutic potential of monocytic cells in Alzheimer's disease (English)

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18 January 2020

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18 January 2020

Tarja Malm

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18 January 2020

Milla Koistinaho

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18 January 2020

Anu Muona

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18 January 2020

Jari Koistinaho

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18 January 2020

language of work or name

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1 June 2010

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18 January 2020

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18 January 2020

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18 January 2020

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18 January 2020

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889-900

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The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.

18 January 2020

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

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Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation.

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7 January 2021

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

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7 January 2021

Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation

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7 January 2021

Minocycline does not affect amyloid beta phagocytosis by human microglial cells

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Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin

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7 January 2021

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7 January 2021

Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain

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7 January 2021

Blood monocytes consist of two principal subsets with distinct migratory properties

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7 January 2021

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

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7 January 2021

Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease

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Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

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7 January 2021

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7 January 2021

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

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7 January 2021

Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia

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7 January 2021

Uptake of Abeta 1-40- and Abeta 1-42-coated yeast by microglial cells: a role for LRP.

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7 January 2021

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

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7 January 2021

Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier

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7 January 2021

Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease

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7 January 2021

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7 January 2021

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7 January 2021

Minocycline reduces engraftment and activation of bone marrow-derived cells but sustains their phagocytic activity in a mouse model of Alzheimer's disease.

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7 January 2021

Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.

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7 January 2021

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons

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7 January 2021

Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

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7 January 2021

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7 January 2021

Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease

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7 January 2021

Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease

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7 January 2021

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

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7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

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7 January 2021

Analysis of Fcγ receptors on human peripheral blood leukocytes by flow microfluorometry. I. Receptor distributions on monocytes, Tγ cells and cells labeled with the 3A1 anti-T cell monoclonal antibody

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7 January 2021

Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors

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7 January 2021

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

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7 January 2021

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

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7 January 2021

Traumatic brain injury and Alzheimer's disease: a review

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Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats

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7 January 2021

Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

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7 January 2021

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7 January 2021

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

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7 January 2021

Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice.

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7 January 2021

Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice

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7 January 2021

The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice.

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7 January 2021

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

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7 January 2021

Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia

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7 January 2021

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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7 January 2021

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy.

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7 January 2021

Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.

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7 January 2021

Definition of human blood monocytes

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7 January 2021

New therapeutic targets in the neurovascular pathway in Alzheimer's disease

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7 January 2021