Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux (Q37679508)

21 August 2017

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux (English)

1 reference

21 August 2017

Richard E Lee

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Bernd Meibohm

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Julian G Hurdle

1 reference

21 August 2017

Jiuyu Liu

1 reference

21 August 2017

David F Bruhn

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21 August 2017

Tanja Matt

1 reference

21 August 2017

Michael S Scherman

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21 August 2017

Pavan K Vaddady

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21 August 2017

Zhong Zheng

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21 August 2017

Jianjun Qi

1 reference

21 August 2017

Rashid Akbergenov

1 reference

21 August 2017

Sourav Das

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21 August 2017

Dora B Madhura

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21 August 2017

Chetan Rathi

1 reference

21 August 2017

Ashit Trivedi

1 reference

21 August 2017

Cristina Villellas

1 reference

21 August 2017

Robin B Lee

1 reference

21 August 2017

Rakesh

1 reference

21 August 2017

Samanthi L Waidyarachchi

1 reference

21 August 2017

Dianqing Sun

1 reference

21 August 2017

Michael R McNeil

1 reference

21 August 2017

Jose A Ainsa

1 reference

21 August 2017

Helena I Boshoff

1 reference

21 August 2017

Mercedes Gonzalez-Juarrero

1 reference

21 August 2017

Erik C Böttger

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21 August 2017

Anne J Lenaerts

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21 August 2017

language of work or name

English

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publication date

26 January 2014

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21 August 2017

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21 August 2017

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21 August 2017

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21 August 2017

152-158

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Pharmacokinetic profile of spectinomycin in rats

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

A medicinal chemists' guide to the unique difficulties of lead optimization for tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Natural products as sources of new drugs over the 30 years from 1981 to 2010

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Challenges of antibacterial discovery

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

A medicinal chemist's guide to molecular interactions

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

A simple in vitro PK/PD model system to determine time-kill curves of drugs against Mycobacteria

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Mitochondrial deafness alleles confer misreading of the genetic code

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

A Steric Block in Translation Caused by the Antibiotic Spectinomycin

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

In vivo and in organello analyses of mitochondrial translation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Tigecycline: a new glycylcycline for treatment of serious infections

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Antimicrobial pharmacodynamics: critical interactions of 'bug and drug'.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Rapid in vivo screening of experimental drugs for tuberculosis using gamma interferon gene-disrupted mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Quantitative drug susceptibility testing of Mycobacterium tuberculosis by use of MGIT 960 and EpiCenter instrumentation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Preparation of 7-deoxyspectinomycin and 7-deoxy-8-epi-4(R)-dihydrospectinomycin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Spectinomycin chemistry. II. 9-Deoxy-4(R)-dihydrospectinomycin and 9-deoxyspectinomycin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Ototoxicity of spectinomycin (author's transl)

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Spectinomycin modification. I. 7-Epi-9-deoxy-4(R)-dihydrospectinomycin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Isolation and subfractionation of mitochondria from animal cells and tissue culture lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Mycobacterium tuberculosis cell envelope

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Structural basis for selectivity and toxicity of ribosomal antibiotics

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Preclinical pharmacology of GAR-936, a novel glycylcycline antibacterial agent.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

The tolerance of high dose intravenous spectinomycin therapy in man.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Principles and applications of halogen bonding in medicinal chemistry and chemical biology

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Conservation of bacterial protein synthesis machinery: initiation and elongation in Mycobacterium smegmatis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Modification of spectinomycin. 2. Derivatives of 4-dihydro-4-deoxy-4(R)-aminospectinomycin.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Directed mutagenesis of Mycobacterium smegmatis 16S rRNA to reconstruct the in vivo evolution of aminoglycoside resistance in Mycobacterium tuberculosis

2 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972818

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

2 October 2018

1 reference

12 December 2020

Preclinical testing of new drugs for tuberculosis: current challenges

1 reference

12 December 2020

Isolation and incubation conditions to study heart mitochondrial protein synthesis

1 reference

12 December 2020

Intramolecular hydrogen bonding in medicinal chemistry

1 reference

12 December 2020

XCL1 (lymphotactin) chemokine produced by activated CD8 T cells during the chronic stage of infection with Mycobacterium tuberculosis negatively affects production of IFN-γ by CD4 T cells and participates in granuloma stability

1 reference

12 December 2020

Modification of spectinomycin. 1. Synthesis of 4-aminospectinomycins

1 reference

12 December 2020

Spectinomycin modification. III. Spectinomycin analogs with C-3'-branched chain sugars

1 reference

12 December 2020

On the structure of hygromycin. The location of a methylene substituent and the anomeric configuration of the arabino-hexoside moiety

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3458

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.3458

1 reference

Dimensions Publication ID

21 August 2017

0 references

1 reference

21 August 2017

PubMed publication ID

24464186

1 reference