From pathogenesis to treatment of chronic lymphocytic leukaemia (Q37643423)

21 August 2017

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title

From pathogenesis to treatment of chronic lymphocytic leukaemia (English)

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21 August 2017

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Ralf Küppers

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Stephan Stilgenbauer

series ordinal

object named as

Stephan Stilgenbauer

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Daniel Mertens

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Hartmut Döhner

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21 August 2017

Thorsten Zenz

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21 August 2017

language of work or name

English

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publication date

3 December 2009

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21 August 2017

published in

Nature Reviews Cancer

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

37-50

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Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells

21 August 2017

cites work

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Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation

21 January 2018

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In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

21 January 2018

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The triterpenoid CDDO induces apoptosis in refractory CLL B cells

21 January 2018

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Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

21 January 2018

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Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology

21 January 2018

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Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database

31 March 2020

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Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

31 March 2020

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Chronic lymphocytic leukemia

31 March 2020

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A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis

31 March 2020

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Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

31 March 2020

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Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted Vlambda2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope.

31 March 2020

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The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process.

31 March 2020

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Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene

31 March 2020

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Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.

31 March 2020

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The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

31 March 2020

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

31 March 2020

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miR-15 and miR-16 induce apoptosis by targeting BCL2

31 March 2020

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Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia

31 March 2020

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Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.

31 March 2020

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Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

31 March 2020

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Genomic aberrations and survival in chronic lymphocytic leukemia

31 March 2020

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Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up

31 March 2020

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Germinal centres: role in B-cell physiology and malignancy

31 March 2020

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Mechanisms of B-cell lymphoma pathogenesis

31 March 2020

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Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia - long-term follow up of patients with different percentages of mutations

31 March 2020

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Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.

31 March 2020

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Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.

31 March 2020

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Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

31 March 2020

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Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

31 March 2020

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B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

31 March 2020

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Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations

31 March 2020

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Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival

31 March 2020

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The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia

31 March 2020

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ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

31 March 2020

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Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

31 March 2020

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Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

31 March 2020

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BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.

31 March 2020

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Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy

31 March 2020

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Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia.

31 March 2020

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Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3.

31 March 2020

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Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

31 March 2020

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Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins

31 March 2020

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Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.

31 March 2020

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B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor

31 March 2020

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Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity

31 March 2020

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A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

31 March 2020

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Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection

31 March 2020

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Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia

31 March 2020

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Features of the overexpressed V1-69 genes in the unmutated subset of chronic lymphocytic leukemia are distinct from those in the healthy elderly repertoire

31 March 2020

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Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial

31 March 2020

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Comprehensive assessment of genetic and molecular features predicting outcome in patients with chronic lymphocytic leukemia: results from the US Intergroup Phase III Trial E2997.

31 March 2020

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Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA.

31 March 2020

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New perspectives in B-1 B cell development and function

31 March 2020

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Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.

31 March 2020

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Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells

31 March 2020

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Human marginal zone B cells.

31 March 2020

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Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase

31 March 2020

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Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes

31 March 2020

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

31 March 2020

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Somatic hypermutation in the heavy chain locus correlates with transcription

31 March 2020

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Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells

31 March 2020

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IgG+, CD5+ human chronic lymphocytic leukemia B cells. Production of IgG antibodies that exhibit diminished autoreactivity and IgG subclass skewing.

31 March 2020

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Identification and characterization of circulating human transitional B cells

31 March 2020

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Exclusion of natural autoantibody-producing B cells from IgG memory B cell compartment during T cell-dependent immune responses.

31 March 2020

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Chronic lymphocytic leukemia: revelations from the B-cell receptor.

31 March 2020

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Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts

31 March 2020

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Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach

31 March 2020

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Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion.

31 March 2020

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B-cell clones as early markers for chronic lymphocytic leukemia

31 March 2020

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Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

31 March 2020

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The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring

31 March 2020

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Overview of monoclonal B-cell lymphocytosis

31 March 2020

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Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism

31 March 2020

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Identification of novel genes coding for small expressed RNAs

31 March 2020

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The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

31 March 2020

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

31 March 2020

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ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

31 March 2020

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Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes

31 March 2020

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Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B.

31 March 2020

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Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.

31 March 2020

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Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping

31 March 2020

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Mechanisms of chromosomal translocations in B cell lymphomas

31 March 2020

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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia

31 March 2020

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Interferon regulatory factor 4 and 8 in B-cell development

31 March 2020

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Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets

31 March 2020

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The death-associated protein kinases: structure, function, and beyond

31 March 2020

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Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?

31 March 2020

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Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22

31 March 2020

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High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

31 March 2020

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Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

31 March 2020

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Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia.

31 March 2020

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CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

31 March 2020

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CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells

31 March 2020

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CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival

31 March 2020

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Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.

31 March 2020

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Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival

31 March 2020

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Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia

31 March 2020

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APRIL promotes B-1 cell-associated neoplasm.

31 March 2020

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Results of a phase 1 clinical trial of thalidomide in combination with fludarabine as initial therapy for patients with treatment-requiring chronic lymphocytic leukemia (CLL).

31 March 2020

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Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia

31 March 2020

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Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia

31 March 2020

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Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia

31 March 2020

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Improving survival in patients with chronic lymphocytic leukemia (1980-2008): the Hospital Clinic of Barcelona experience

31 March 2020

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Fludarabine plus cyclophosphamide versus fludarabine alone in first-line therapy of younger patients with chronic lymphocytic leukemia

31 March 2020

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Characteristics associated with important clinical end points in patients with chronic lymphocytic leukemia at initial treatment

31 March 2020

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ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

31 March 2020

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Indications for allogeneic stem cell transplantation in chronic lymphocytic leukemia: the EBMT transplant consensus.

31 March 2020

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How little is too much? p53 inactivation: from laboratory cutoff to biological basis of chemotherapy resistance

31 March 2020

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The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness.

31 March 2020

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miR-34a as part of the resistance network in chronic lymphocytic leukemia

31 March 2020

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p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation

31 March 2020

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Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

31 March 2020

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Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly

31 March 2020

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Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

31 March 2020

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

31 March 2020

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Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

31 March 2020

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ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

31 March 2020

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Additional genetic high-risk features such as 11q deletion, 17p deletion, and V3-21 usage characterize discordance of ZAP-70 and VH mutation status in chronic lymphocytic leukemia

31 March 2020

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How I treat refractory CLL.

31 March 2020

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Imaging of germinal center selection events during affinity maturation

31 March 2020

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MiR-15a and miR-16-1 cluster functions in human leukemia

31 March 2020

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ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile

31 March 2020

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Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia

31 March 2020

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Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia.

31 March 2020

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Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia

31 March 2020

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Genetics and risk-stratified approach to therapy in chronic lymphocytic leukemia

31 March 2020

1 reference

Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group

31 March 2020

1 reference

Depsipeptide (FR901228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells.

31 March 2020

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12 December 2020

The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL

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12 December 2020

Differential effects on CLL cell survival exerted by different microenvironmental elements

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12 December 2020

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

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12 December 2020

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.

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12 December 2020

V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia.

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12 December 2020

Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment

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12 December 2020

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

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12 December 2020

Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities

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12 December 2020

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia

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12 December 2020

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

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12 December 2020

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

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12 December 2020

Clinical staging of chronic lymphocytic leukemia

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12 December 2020

Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.

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12 December 2020

Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells

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12 December 2020

New insights into the phenotype and cell derivation of B cell chronic lymphocytic leukemia

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12 December 2020

BCL-6 expression during B-cell activation

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12 December 2020

11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis

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12 December 2020

p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias

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12 December 2020

Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation

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12 December 2020

BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia

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12 December 2020

ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia

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12 December 2020

Identifiers

DOI

10.1038/NRC2764

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21 August 2017

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