From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). (Q37561359)

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27 March 2020

review article

2 references

17 December 2020

From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs) (English)

1 reference

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27 March 2020

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29 May 2020

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13 December 2019

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17 December 2020

antineoplastic antibiotics

1 reference

27862776

anthramycin

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27862776

benzodiazepine drug

1 reference

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27 March 2020

1 reference

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27 March 2020

Julia Mantaj

1 reference

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27 March 2020

Paul J M Jackson

series ordinal

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English

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publication date

15 November 2016

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Angewandte Chemie International Edition

27 March 2020

9 January 2017

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8 references

13 March 2019

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3 April 2019

27 November 2019

13 December 2019

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27 March 2020

17 December 2020

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page(s)

462-488

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Creative Commons Attribution-NonCommercial-NoDerivatives

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on focus list of Wikimedia project

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14 September 2017

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25 June 2018

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25 June 2018

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Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies

25 June 2018

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An agarose gel method for the determination of DNA interstrand crosslinking applicable to the measurement of the rate of total and "second-arm" crosslink reactions

25 June 2018

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25 June 2018

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Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition

25 June 2018

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SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

1 September 2018

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1 September 2018

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Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

1 September 2018

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Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5215561

DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5215561

Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5215561

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5215561

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 September 2018

1 reference

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Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity

1 September 2018

1 reference

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Design and synthesis of a novel DNA-DNA interstrand adenine-guanine cross-linking agent

1 September 2018

1 reference

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A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity.

1 September 2018

1 reference

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Isolation and Characterization of Anthramycin, a New Antitumor Antibiotic

1 September 2018

1 reference

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Antibody-drug conjugates as novel anti-cancer chemotherapeutics

1 September 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

Abstract 1129: GC-t8-linked pyrrolobenzodiazepine (PBD)-biaryl conjugates with femptomolar in vitrocytotoxicity andin vivoantitumour activity in mouse models of pancreatic and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

LC–MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines†

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201510610

[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1

21 January 2018

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12 December 2020

Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

1 reference

12 December 2020

Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling

1 reference

12 December 2020

Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study

1 reference

12 December 2020

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy

1 reference

12 December 2020

Nuclear Magnetic Resonance Solution Structures of Inter- and Intrastrand Adducts of DNA Cross-Linker SJG-136

1 reference

12 December 2020

Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box

1 reference

12 December 2020

Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC

1 reference

12 December 2020

γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000)

1 reference

12 December 2020

Two-dimensional NMR studies on the anthramycin-d(ATGCAT)2 adduct

1 reference

12 December 2020

Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

1 reference

12 December 2020

Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA

1 reference

12 December 2020

Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin

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12 December 2020

Chemosterilant action of anthramycin: a proposed mechanism

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12 December 2020

Reaction of anthramycin with deoxyribonucleic acid

1 reference

12 December 2020

Clinical Investigation of Cancer Chemotherapeutic Agents for Neoplastic Disease

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12 December 2020

Chicamycin, a new antitumor antibiotic. I. Production, isolation and properties

1 reference

12 December 2020

A total synthesis of chicamycin A a new pyrrolo[1,4]benzodiazepine antitumor agent

1 reference

12 December 2020

Chemical conversion of anthramycin 11-methyl ether to didehydroanhydroanthramycin and its utilization in studies of the biosynthesis and mechanism of action of anthramycin

1 reference

12 December 2020

Antitumor effect of a new antibiotic, neothramycin

1 reference

12 December 2020

Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking

1 reference

12 December 2020

In vivo-in vitro correlation of myelotoxicity of 9-methoxypyrazoloacridine (NSC-366140, PD115934) to myeloid and erythroid hematopoietic progenitors from human, murine, and canine marrow

1 reference

12 December 2020

Preclinical pharmacology and antitumour activity of the novel sequence-selective DNA minor-groove cross-linking agent DSB-120

1 reference

12 December 2020

Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines

1 reference

12 December 2020

Identifiers

DOI

10.1002/ANIE.201510610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27862776%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27862776%20AND%20SRC:MED&resulttype=core&format=json

27 March 2020

27862776

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27862776%20AND%20SRC:MED&resulttype=core&format=json