Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors. (Q35024036)

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English	Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.	scientific article

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scholarly article

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stated in

Europe PubMed Central

PMC publication ID

3107910

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

title

Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors (English)

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stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

main subject

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author

Igor Puzanov

series ordinal

1

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Wooin Lee

series ordinal

2

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

author name string

Alice P Chen

series ordinal

3

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

M Wade Calcutt

series ordinal

4

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

David L Hachey

series ordinal

5

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Wendy L Vermeulen

series ordinal

6

1 reference

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Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Victoria J Spanswick

series ordinal

7

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Chih-Yi Liao

series ordinal

8

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

John A Hartley

series ordinal

9

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Jordan D Berlin

series ordinal

10

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Mace L Rothenberg

series ordinal

11

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

language of work or name

English

0 references

publication date

23 February 2011

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

published in

Clinical Cancer Research

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

volume

17

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

issue

11

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

page(s)

3794-3802

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

cites work

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107910

retrieved

8 July 2018

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107910

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8 July 2018

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity

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PubMed Central

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8 July 2018

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

1 reference

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107910

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8 July 2018

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity

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PubMed Central

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8 July 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

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PubMed Central

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107910

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8 July 2018

Synthetic DNA minor groove-binding drugs

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PubMed Central

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8 July 2018

DNA adducts from chemotherapeutic agents

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PubMed Central

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8 July 2018

Measurement of drug-induced DNA interstrand crosslinking using the single-cell gel electrophoresis (comet) assay.

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PubMed Central

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25 October 2018

Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors

1 reference

stated in

PubMed Central

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3107910

retrieved

25 October 2018

Determination of chemically reduced pyrrolobenzodiazepine SJG-136 in human plasma by HPLC-MS/MS: application to an anticancer phase I dose escalation study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21346148

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Titration Designs for Phase I Clinical Trials in Oncology

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21346148

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/1078-0432.CCR-10-2056

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

PMC publication ID

3107910

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

PubMed publication ID

21346148

1 reference

stated in

Europe PubMed Central

PMC publication ID

3107910

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21346148%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

 

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