BH3-only proteins and their roles in programmed cell death (Q37566201)

21 August 2017

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title

BH3-only proteins and their roles in programmed cell death (English)

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21 August 2017

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P Bouillet

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M Giam

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21 August 2017

D C S Huang

series ordinal

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21 August 2017

language of work or name

English

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publication date

1 December 2008

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21 August 2017

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21 August 2017

volume

27 Suppl 1

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21 August 2017

page(s)

S128-36

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription

31 March 2020

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

Solution structure of BID, an intracellular amplifier of apoptotic signaling

31 March 2020

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The Bcl2 family: regulators of the cellular life-or-death switch

31 March 2020

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

31 March 2020

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BAX activation is initiated at a novel interaction site

31 March 2020

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Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

31 March 2020

1 reference

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Apoptosis: Stabbed in the BAX.

31 March 2020

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Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

31 March 2020

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Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

31 March 2020

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The pleiotropic effects of heterologous Bax expression in yeast.

31 March 2020

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JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

31 March 2020

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

31 March 2020

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

31 March 2020

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

31 March 2020

1 reference

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

31 March 2020

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.50

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

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Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

31 March 2020

1 reference

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Conformation of the Bax C-terminus regulates subcellular location and cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

31 March 2020

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

31 March 2020

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Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

31 March 2020

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

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Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

The role of BH3-only proteins in the immune system

31 March 2020

1 reference

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bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

31 March 2020

1 reference

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What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain

31 March 2020

1 reference

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Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

31 March 2020

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Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

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How the Bcl-2 family of proteins interact to regulate apoptosis.

31 March 2020

1 reference

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

A stapled BID BH3 helix directly binds and activates BAX

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Life in the balance: how BH3-only proteins induce apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.50

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.50

1 reference

21 August 2017

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