Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes (Q37481309)

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scientific article published on February 2009

Language	Label	Description	Also known as
English	Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes	scientific article published on February 2009

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

1 reference

Europe PubMed Central

Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

G protein-coupled receptor

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type 2 diabetes

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author name string

Sandip B Bharate

1

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Kumar V S Nemmani

2

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Ram A Vishwakarma

3

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

language of work or name

0 references

publication date

1 February 2009

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Expert Opinion on Therapeutic Patents

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

237-264

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

Stimulation of insulin secretion by infusion of free fatty acids

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Free fatty acid receptors and drug discovery

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Modulation of insulin secretion by fatty acyl analogs

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

G protein-coupled receptors and insulin secretion: 119 and counting

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Fatty acid receptors as new therapeutic targets for diabetes

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

G protein-coupled receptors for free fatty acids.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Role of GPR40 in fatty acid action on the beta cell line INS-1E.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Discovery of new G protein-coupled receptors for lipid mediators

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The ins and outs of fatty acids on the pancreatic beta cell

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

G-protein-coupled receptors at a glance

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Continued discovery of ligands for G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Synthesis and activity of small molecule GPR40 agonists

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Identification of residues important for agonist recognition and activation in GPR40

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Activation of mitogen-activated protein kinases by peroxisome proliferator-activated receptor ligands: an example of nongenomic signaling

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5'-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin.

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

GIP biology and fat metabolism

1 reference

https://api.crossref.org/works/10.1517%2F13543770802665717

21 January 2018

Identifiers

10.1517/13543770802665717

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 August 2017

ResearchGate publication ID

0 references

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