Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. (Q37436541)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19616616%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine (English)

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2 February 2020

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2 February 2020

Sally P Stabler

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2 February 2020

Jeevan Sekhar

series ordinal

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2 February 2020

Robert H Allen

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2 February 2020

Carl W White

series ordinal

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2 February 2020

publication date

17 July 2009

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Free Radical Biology and Medicine

2 February 2020

published in

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2 February 2020

volume

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2 February 2020

issue

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2 February 2020

page(s)

1147-1153

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The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects.

2 February 2020

cites work

1 reference

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Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans

23 August 2017

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Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.

23 August 2017

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S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity

23 August 2017

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Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and the enzymatic recycling method: application to the rat liver and bile samples

23 August 2017

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S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy

23 August 2017

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Effect of drugs on homocysteine concentrations

23 August 2017

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Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats

23 August 2017

1 reference

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(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

23 August 2017

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α-Lipoic Acid and Cardiovascular Disease

23 August 2017

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Plasma Kinetics, Metabolism, and Urinary Excretion of Alpha‐Lipoic Acid following Oral Administration in Healthy Volunteers

23 August 2017

1 reference

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New metabolic pathways of alpha-lipoic acid

23 August 2017

1 reference

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Pathways and regulation of homocysteine metabolism in mammals

23 August 2017

1 reference

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Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver

23 August 2017

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Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism

23 August 2017

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Alpha-lipoic acid as a biological antioxidant

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Elimination of high amounts of extracellular homocysteine in human cell lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Early lipoic acid intake protects retina of diabetic mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Methyl balance and transmethylation fluxes in humans.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Lipoic acid supplementation prevents angiotensin II-induced renal injury

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2782850

Chromatographic analysis of lipoic acid and related compounds

2 September 2018

1 reference

12 December 2020

Methylation demand and homocysteine metabolism

1 reference

12 December 2020

Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson's disease patients

1 reference

12 December 2020

alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet

1 reference

12 December 2020

Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats

1 reference

12 December 2020

Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative

1 reference

12 December 2020

Mesna as a Nonvitamin Intervention to Lower Plasma Total Homocysteine Concentration: Implications for Assessment of the Homocysteine Theory of Atherosclerosis

1 reference

12 December 2020

10.1016/J.FREERADBIOMED.2009.07.019

Identifiers

DOI

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2 February 2020

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2 February 2020

PubMed publication ID

19616616

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19616616%20AND%20SRC:MED&resulttype=core&format=json