Wnt signaling in bone metabolism (Q37427485)

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scientific article published on 31 March 2009

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English	Wnt signaling in bone metabolism	scientific article published on 31 March 2009

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instance of

scholarly article

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Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

review article

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Europe PubMed Central

title

Wnt signaling in bone metabolism (English)

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Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

author name string

Takuo Kubota

series ordinal

1

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Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

Toshimi Michigami

series ordinal

2

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stated in

Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

Keiichi Ozono

series ordinal

3

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Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

publication date

31 March 2009

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Europe PubMed Central

PubMed publication ID

19333681

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20 August 2017

published in

Journal of Bone and Mineral Metabolism

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Europe PubMed Central

PubMed publication ID

19333681

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20 August 2017

volume

27

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Europe PubMed Central

PubMed publication ID

19333681

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20 August 2017

issue

3

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Europe PubMed Central

PubMed publication ID

19333681

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20 August 2017

page(s)

265-271

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Europe PubMed Central

PubMed publication ID

19333681

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20 August 2017

cites work

Genetic regulation of bone mass and susceptibility to osteoporosis

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https://pubmed.ncbi.nlm.nih.gov/19333681

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The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

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https://pubmed.ncbi.nlm.nih.gov/19333681

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The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment

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https://pubmed.ncbi.nlm.nih.gov/19333681

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Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

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https://pubmed.ncbi.nlm.nih.gov/19333681

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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WNT and beta-catenin signalling: diseases and therapies

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Glycogen synthase kinase-3: properties, functions, and regulation

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12 December 2020

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Control of bone mass and remodeling by PTH receptor signaling in osteocytes

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

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12 December 2020

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The osteocyte lineage

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Regulation of osteoblastogenesis and bone mass by Wnt10b

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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inferred from PubMed ID database lookup

Regulation of bone mass by Wnt signaling

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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An LDL-receptor-related protein mediates Wnt signalling in mice

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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In vivo analysis of Wnt signaling in bone

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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The Wnt signaling pathway in development and disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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inferred from PubMed ID database lookup

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTH stimulates bone formation in mice deficient in Lrp5

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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inferred from PubMed ID database lookup

SOST is a target gene for PTH in bone

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of osteoporosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Molecular genetic studies of gene identification for osteoporosis: a 2004 update

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Sequential roles of Hedgehog and Wnt signaling in osteoblast development

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Control of the SOST bone enhancer by PTH using MEF2 transcription factors

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

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Clinical and molecular findings in osteoporosis-pseudoglioma syndrome

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12 December 2020

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Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

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12 December 2020

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Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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High bone density due to a mutation in LDL-receptor-related protein 5

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Osteocytes, mechanosensing and Wnt signaling

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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High bone mass in mice expressing a mutant LRP5 gene

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Wnt signaling and skeletal development

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

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12 December 2020

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Inhibition of adipogenesis by Wnt signaling

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12 December 2020

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

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12 December 2020

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Wnt/beta-catenin signaling: new (and old) players and new insights

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12 December 2020

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Osteoporosis prevention, diagnosis, and therapy

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

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12 December 2020

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Fracture risk associated with parkinsonism and anti-Parkinson drugs

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12 December 2020

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GSK-3beta controls osteogenesis through regulating Runx2 activity

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12 December 2020

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Wnt signalling in development and disease. Max Delbrück Center for Molecular Medicine meeting on Wnt signaling in Development and Disease

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma

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12 December 2020

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Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene Expression

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12 December 2020

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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12 December 2020

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The genetics of low-density lipoprotein receptor-related protein 5 in bone: a story of extremes

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in development and disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19333681

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

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12 December 2020

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Essential role of beta-catenin in postnatal bone acquisition

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12 December 2020

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LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way

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https://pubmed.ncbi.nlm.nih.gov/19333681

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12 December 2020

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Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro

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12 December 2020

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Identifiers

DOI

10.1007/S00774-009-0064-8

1 reference

stated in

Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

PubMed publication ID

19333681

1 reference

stated in

Europe PubMed Central

PubMed publication ID

19333681

retrieved

20 August 2017

ResearchGate publication ID

24245958

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