Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. (Q37331720)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332865%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors (English)

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4 January 2020

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4 January 2020

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4 January 2020

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4 January 2020

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4 January 2020

1 reference

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4 January 2020

L S Steelman

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4 January 2020

P M Navolanic

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4 January 2020

M L Sokolosky

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4 January 2020

J R Taylor

1 reference

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4 January 2020

W H Chappell

1 reference

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4 January 2020

S L Abrams

1 reference

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4 January 2020

E W T Wong

1 reference

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4 January 2020

K M Stadelman

1 reference

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4 January 2020

D M Terrian

1 reference

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4 January 2020

A M Martelli

1 reference

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4 January 2020

F Stivala

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4 January 2020

language of work or name

English

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publication date

10 March 2008

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4 January 2020

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4 January 2020

volume

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4 January 2020

issue

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4 January 2020

page(s)

4086-4095

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Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside

4 January 2020

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

6 September 2017

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PTEN: one gene, many syndromes

6 September 2017

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Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

6 September 2017

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

6 September 2017

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

6 September 2017

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Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis

6 September 2017

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The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.

6 September 2017

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

6 September 2017

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

6 September 2017

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

6 September 2017

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The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

6 September 2017

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A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells.

14 September 2017

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ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells

14 September 2017

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Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer

14 September 2017

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Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis

14 September 2017

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Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis

14 September 2017

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14 September 2017

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Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

14 September 2017

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14 September 2017

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28 September 2017

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High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma

26 June 2018

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Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma

2 September 2018

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2 September 2018

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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

2 September 2018

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Reduced expression of PTEN correlates with breast cancer progression

2 September 2018

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The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

2 September 2018

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Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

2 September 2018

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

2 September 2018

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Promoter methylation of the PTEN gene is a common molecular change in breast cancer

31 March 2020

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Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast

31 March 2020

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Activation of PI3K/Akt signaling and hormone resistance in breast cancer

31 March 2020

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Reduced expression of PTEN protein and its prognostic implications in invasive ductal carcinoma of the breast

31 March 2020

1 reference

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Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18332865

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18332865

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332865%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332865%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

18332865

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18332865%20AND%20SRC:MED&resulttype=core&format=json