Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition (Q37253319)

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scientific article published on 23 June 2009

Language	Label	Description	Also known as
English	Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition	scientific article published on 23 June 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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1 reference

based on heuristic

inferred from title

Scott B Rothbart

2

object named as

Scott B Rothbart

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Europe PubMed Central

PMC publication ID

19 August 2017

author name string

Alexandra C Racanelli

1

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Europe PubMed Central

PMC publication ID

19 August 2017

Cortney L Heyer

3

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Europe PubMed Central

PMC publication ID

19 August 2017

Richard G Moran

4

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Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

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publication date

23 June 2009

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Europe PubMed Central

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19 August 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

19 August 2017

69

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Europe PubMed Central

PMC publication ID

19 August 2017

13

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

5467-5474

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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1 reference

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

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1 reference

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

1 reference

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Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

1 reference

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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The 6S- and 6R-diastereomers of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate are equiactive inhibitors of de novo purine synthesis

1 reference

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Role of thymidylate synthetase activity in development of methotrexate cytotoxicity

1 reference

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Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

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1 reference

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Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells

1 reference

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Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1 reference

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Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

1 reference

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The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line

1 reference

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5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase

1 reference

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Tight Binding of Folate Substrates and Inhibitors to Recombinant Mouse Glycinamide Ribonucleotide Formyltransferase

1 reference

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5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2706929

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1 reference

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1 reference

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1 reference

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THE ENZYMOLOGY OF FEEDBACK INHIBITION OF GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE BY PURINE RIBONUCLEOTIDES.

1 reference

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A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

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Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.

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Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19549896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19549896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feedback Control of Purine Biosynthesis by Purine Ribonucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19549896

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-08-4979

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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