High antigen levels are the cause of T cell exhaustion during chronic viral infection (Q37208927)

19 August 2017

High antigen levels are the cause of T cell exhaustion during chronic viral infection (English)

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19 August 2017

1 reference

Rafi Ahmed

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19 August 2017

Scott N Mueller

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19 August 2017

language of work or name

English

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publication date

11 May 2009

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Proceedings of the National Academy of Sciences of the United States of America

19 August 2017

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19 August 2017

106

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19 August 2017

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19 August 2017

8623-8628

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2688997/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

1 reference

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Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

6 September 2017

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Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

6 September 2017

1 reference

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Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

6 September 2017

1 reference

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The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

6 September 2017

1 reference

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Interleukin-10 determines viral clearance or persistence in vivo

6 September 2017

1 reference

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Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

6 September 2017

1 reference

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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

6 September 2017

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

6 September 2017

1 reference

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T cells and viral persistence: lessons from diverse infections

6 September 2017

1 reference

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Antigen-independent memory CD8 T cells do not develop during chronic viral infection

6 September 2017

1 reference

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

6 September 2017

1 reference

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Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

6 September 2017

1 reference

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Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

6 September 2017

1 reference

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Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells

6 September 2017

1 reference

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A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon

6 September 2017

1 reference

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Viral immune evasion due to persistence of activated T cells without effector function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus

6 September 2017

1 reference

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Distribution of dystroglycan in normal adult mouse tissues

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

6 September 2017

1 reference

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Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus

6 September 2017

1 reference

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Immune function in mice lacking the perforin gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Mechanisms of viral clearance and persistence

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Antigen presentation by nonhemopoietic cells amplifies clonal expansion of effector CD8 T cells in a pathogen-specific manner.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Role of thymic output in regulating CD8 T-cell homeostasis during acute and chronic viral infection.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688997

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0809818106

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0809818106

21 January 2018

Identifiers

DOI

10.1073/PNAS.0809818106

1 reference

19 August 2017

0 references

1 reference

19 August 2017

PubMed publication ID

19433785

1 reference