Actions of human telomerase beyond telomeres (Q37198593)

18 August 2017

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title

Actions of human telomerase beyond telomeres (English)

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18 August 2017

Yusheng Cong

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18 August 2017

Jerry W Shay

series ordinal

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18 August 2017

publication date

1 July 2008

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18 August 2017

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

725-732

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Telomere states and cell fates

18 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

The biogenesis and regulation of telomerase holoenzymes

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Human telomerase and its regulation

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7 January 2021

Senescence and immortalization: role of telomeres and telomerase

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7 January 2021

Telomeres: cancer to human aging

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7 January 2021

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

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7 January 2021

BRAFE600-associated senescence-like cell cycle arrest of human naevi

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7 January 2021

Tumour biology: senescence in premalignant tumours

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7 January 2021

Oncogene-induced senescence as an initial barrier in lymphoma development

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7 January 2021

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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7 January 2021

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Restoration of p53 function leads to tumour regression in vivo

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

The common biology of cancer and ageing

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase is not an oncogene

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Inhibition of telomerase limits the growth of human cancer cells.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomeres, telomerase, and human disease

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Adult-onset pulmonary fibrosis caused by mutations in telomerase

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase therapeutics for cancer: challenges and new directions

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

TERT promotes cellular and organismal survival independently of telomerase activity

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Shelterin: the protein complex that shapes and safeguards human telomeres

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

A DNA damage checkpoint response in telomere-initiated senescence

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

DNA damage foci at dysfunctional telomeres

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase maintains telomere structure in normal human cells.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Interactions between telomerase and primase physically link the telomere and chromosome replication machinery

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Human Heterochromatin Protein 1 Isoforms HP1Hsα and HP1Hsβ Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

hTERT associates with human telomeres and enhances genomic stability and DNA repair

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Reconstitution of active telomerase in primary human foreskin fibroblasts: effects on proliferative characteristics and response to ionizing radiation.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

p53-dependent integration of telomere and growth factor deprivation signals

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Soothing the watchman: telomerase reduces the p53-dependent cellular stress response

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Conditional telomerase induction causes proliferation of hair follicle stem cells

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Effects of telomerase and telomere length on epidermal stem cell behavior

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Subnuclear shuttling of human telomerase induced by transformation and DNA damage.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase in the human organism

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomere length, stem cells and aging

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Living with genome instability: plant responses to telomere dysfunction

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Induced pluripotent stem cell lines derived from human somatic cells

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Reprogramming of human somatic cells to pluripotency with defined factors

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Global gene expression response to telomerase in bovine adrenocortical cells

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Genes and pathways downstream of telomerase in melanoma metastasis

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Up-regulation of Mac-2 binding protein by hTERT in gastric cancer

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I.

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Myc activates telomerase

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Risky immortalization by telomerase

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Evidence of extra-telomeric effects of hTERT and its regulation involving a feedback loop

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https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.74

7 January 2021

Identifiers

DOI

10.1038/CR.2008.74

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release_kgzterwajnfx3bfgkzvvodm2qu

18 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/kgzterwajnfx3bfgkzvvodm2qu

24 November 2022

mapped directly with Wikidata item

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