Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. (Q37177892)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19319133%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts (English)

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24 January 2020

1 reference

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24 January 2020

P Cao

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24 January 2020

S-M Maira

series ordinal

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24 January 2020

C García-Echeverría

series ordinal

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24 January 2020

language of work or name

English

0 references

publication date

24 March 2009

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British Journal of Cancer

24 January 2020

published in

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24 January 2020

volume

100

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24 January 2020

issue

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24 January 2020

page(s)

1267-1276

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NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

24 January 2020

cites work

1 reference

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

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6 September 2017

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

6 September 2017

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Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer

6 September 2017

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Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells

14 September 2017

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Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras

14 September 2017

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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

14 September 2017

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Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines

14 September 2017

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Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

14 September 2017

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Role of growth factors in pancreatic cancer.

27 June 2018

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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

27 June 2018

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3 September 2018

Drugging the PI3 kinome

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Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma.

3 September 2018

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Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xe

3 September 2018

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Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells

3 September 2018

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Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma

3 September 2018

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Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

3 September 2018

1 reference

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Wortmannin inhibits pkb/akt phosphorylation and promotes gemcitabine antitumor activity in orthotopic human pancreatic cancer xenografts in immunodeficient mice.

3 September 2018

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Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19319133

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An in vivo platform for translational drug development in pancreatic cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19319133

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6604995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19319133%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19319133%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

19319133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19319133%20AND%20SRC:MED&resulttype=core&format=json