Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines (Q40552877)

21 September 2017

title

Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines (English)

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21 September 2017

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Daniel DeArmond

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21 September 2017

Michael G Brattain

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21 September 2017

John Milburn Jessup

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21 September 2017

Jeffrey Kreisberg

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21 September 2017

Shazli Malik

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21 September 2017

Shujie Zhao

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21 September 2017

James W Freeman

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21 September 2017

language of work or name

English

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publication date

1 October 2003

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21 September 2017

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21 September 2017

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21 September 2017

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21 September 2017

page(s)

7781-7795

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

21 September 2017

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

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Increased tumorigenicity in the human pancreatic cell line MIA PaCa-2 is associated with an aberrant regulation of an IGF-1 autocrine loop and lack of expression of the TGF-beta type RII receptor

21 January 2018

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Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

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Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation

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Signaling through the hematopoietic cytokine receptors.

21 January 2018

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STAT3 is required for the gp130-mediated full activation of the c-myc gene

21 January 2018

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Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha

21 January 2018

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ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

21 January 2018

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Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity

21 January 2018

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c-erbB-2 overexpression and histological type of in situ and invasive breast carcinoma

21 January 2018

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Autocrine secretion and malignant transformation of cells.

21 January 2018

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The Janus kinase family of protein tyrosine kinases and their role in signaling

21 January 2018

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Aberrations of the G1- and G1/S-regulating genes in human cancer

21 January 2018

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7 January 2021

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

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7 January 2021

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7 January 2021

HER2/neu: mechanisms of dimerization/oligomerization

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7 January 2021

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

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7 January 2021

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

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7 January 2021

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

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7 January 2021

Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

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7 January 2021

STATs and Gene Regulation

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7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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7 January 2021

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

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7 January 2021

HER-2/neu expression in pancreatic adenocarcinoma: relation to tumor differentiation and survival

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7 January 2021

Characterization of a newly established human pancreatic carcinoma cell line, UK Pan-1.

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7 January 2021

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

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7 January 2021

A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription

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7 January 2021

The c-erb B-2 proto-oncogene in human pancreatic cancer

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7 January 2021

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

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7 January 2021

Aberrant regulation of transforming growth factor-alpha during the establishment of growth arrest and quiescence of growth factor independent cells

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7 January 2021

Regulation of Transforming Growth Factor α Expression in a Growth Factor-Independent Cell Line

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7 January 2021

STATs: signal transducers and activators of transcription

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7 January 2021

Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206966

7 January 2021

Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinico-histopathological correlation in a series of 75 cases

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7 January 2021

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206966

7 January 2021

Regulation of STAT-dependent pathways by growth factors and cytokines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206966

7 January 2021

Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor

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7 January 2021

Tyrosine kinase inhibition: an approach to drug development

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7 January 2021

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor

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7 January 2021

An immunohistochemical study of the c-erbB-2 oncogene product in intraductal mucin-hypersecreting neoplasms and in ductal cell carcinomas of the pancreas

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7 January 2021

Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).

1 reference

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7 January 2021

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

1 reference

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7 January 2021

Autocrine growth factors and cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206966

7 January 2021

p21 is a universal inhibitor of cyclin kinases

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206966

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Dimensions Publication ID

21 September 2017

1019332353

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1 reference