Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model (Q37102130)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

0 references

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

Shreyasi Chatterjee

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

George M Lawless

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

George R Jackson

series ordinal

1 reference

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24 December 2019

language of work or name

1 reference

17 October 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

published in

Human Molecular Genetics

1 reference

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24 December 2019

volume

1 reference

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24 December 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

page(s)

164-177

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

24 December 2019

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2644648/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Tau phosphorylation sites work in concert to promote neurotoxicity in vivo

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

14 September 2017

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14 September 2017

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Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice

14 September 2017

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Tau filament formation in transgenic mice expressing P301L tau.

14 September 2017

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

14 September 2017

1 reference

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A class VI unconventional myosin is associated with a homologue of a microtubule-binding protein, cytoplasmic linker protein-170, in neurons and at the posterior pole of Drosophila embryos

14 September 2017

1 reference

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

14 September 2017

1 reference

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14 September 2017

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

14 September 2017

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

14 September 2017

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

14 September 2017

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Hyperphosphorylation of tau in PHF

14 September 2017

2 references

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14 September 2017

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A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

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Oxidative stress mediates tau-induced neurodegeneration in Drosophila

14 September 2017

1 reference

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

29 September 2017

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Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

29 September 2017

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Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation

27 June 2018

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Phosphorylation of tau by cyclic-AMP-dependent protein kinase.

27 June 2018

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Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease

27 June 2018

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PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta.

27 June 2018

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27 June 2018

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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

27 June 2018

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Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

27 June 2018

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Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice

3 September 2018

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Study of tauopathies by comparing Drosophila and human tau in Drosophila

3 September 2018

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S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

3 September 2018

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Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.

3 September 2018

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Tau binding to microtubules does not directly affect microtubule-based vesicle motility

3 September 2018

1 reference

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Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

3 September 2018

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The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

3 September 2018

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Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila.

3 September 2018

1 reference

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Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.

3 September 2018

1 reference

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Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.

3 September 2018

1 reference

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Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Tau and tau reporters disrupt central projections of sensory neurons in Drosophila.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Modulation of tau phosphorylation and intracellular localization by cellular stress

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

3 September 2018

1 reference

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Overexpression of zeste white 3 blocks wingless signaling in the Drosophila embryonic midgut

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644648

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18930955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDN326

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

18930955

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18930955%20AND%20SRC:MED&resulttype=core&format=json