Systematic screens for human disease genes, from yeast to human and back (Q37030590)

17 August 2017

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title

Systematic screens for human disease genes, from yeast to human and back (English)

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17 August 2017

Lars M Steinmetz

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Fabiana Perocchi

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17 August 2017

Eugenio Mancera

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17 August 2017

publication date

25 September 2007

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17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

18-29

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Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

17 August 2017

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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Mitochondria, oxidants, and aging

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Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae

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Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

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Integrative analysis of the mitochondrial proteome in yeast

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Characterization of the human heart mitochondrial proteome

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Computational method to predict mitochondrially imported proteins and their targeting sequences

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Predicting subcellular localization of proteins based on their N-terminal amino acid sequence

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Global organellar proteomics

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Proteomics of organelles and large cellular structures

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Organellar proteomics: turning inventories into insights

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Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry.

21 January 2018

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Genome-wide analysis of mRNAs targeted to yeast mitochondria

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Systematic identification of human mitochondrial disease genes through integrative genomics

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Assessing systems properties of yeast mitochondria through an interaction map of the organelle

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Proteomic analysis of the mouse liver mitochondrial inner membrane

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Defining transcription modules using large-scale gene expression data

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Cluster analysis and display of genome-wide expression patterns

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Systematic determination of genetic network architecture

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Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters

21 January 2018

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Functional discovery via a compendium of expression profiles

21 January 2018

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Genome-wide location and function of DNA binding proteins

21 January 2018

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Transcriptional regulatory networks in Saccharomyces cerevisiae

21 January 2018

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

21 January 2018

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Global mapping of the yeast genetic interaction network

21 January 2018

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A comprehensive two-hybrid analysis to explore the yeast protein interactome

21 January 2018

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A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

21 January 2018

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Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

21 January 2018

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Proteome survey reveals modularity of the yeast cell machinery

21 January 2018

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Functional organization of the yeast proteome by systematic analysis of protein complexes

21 January 2018

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Global analysis of protein phosphorylation in yeast

21 January 2018

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Analysis of yeast protein kinases using protein chips.

21 January 2018

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Predicting protein function by genomic context: quantitative evaluation and qualitative inferences

21 January 2018

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Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

21 January 2018

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Measuring genome evolution

21 January 2018

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Detecting protein function and protein-protein interactions from genome sequences

21 January 2018

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Protein interaction maps for complete genomes based on gene fusion events

21 January 2018

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Conservation of gene order: a fingerprint of proteins that physically interact

21 January 2018

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The use of gene clusters to infer functional coupling

21 January 2018

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Literature mining for the biologist: from information retrieval to biological discovery

21 January 2018

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MPact: the MIPS protein interaction resource on yeast

21 January 2018

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From genomics to chemical genomics: new developments in KEGG

21 January 2018

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Comparative assessment of large-scale data sets of protein-protein interactions

21 January 2018

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STRING 7--recent developments in the integration and prediction of protein interactions

21 January 2018

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A human protein-protein interaction network: a resource for annotating the proteome

21 January 2018

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Towards a proteome-scale map of the human protein–protein interaction network

21 January 2018

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Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data

21 January 2018

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Systems biology and new technologies enable predictive and preventative medicine.

21 January 2018

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Integrating high-throughput and computational data elucidates bacterial networks

21 January 2018

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Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

21 January 2018

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A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16

21 January 2018

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Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics

21 January 2018

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MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion

21 January 2018

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Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle.

21 January 2018

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The Saccharomyces cerevisiae Pet309 protein is embedded in the mitochondrial inner membrane

21 January 2018

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From syndrome families to functional genomics

21 January 2018

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21 January 2018

Systems biology of SNPs

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The human disease network

21 January 2018

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Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes

21 January 2018

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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

21 January 2018

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Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

21 January 2018

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Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae

21 January 2018

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Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)

21 January 2018

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Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.

21 January 2018

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A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency

21 January 2018

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A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.

21 January 2018

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GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L

21 January 2018

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Using yeast to place human genes in functional categories

21 January 2018

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A Set of Vectors with a Tetracycline-Regulatable Promoter System for Modulated Gene Expression inSaccharomyces cerevisiae

21 January 2018

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Exploration of essential gene functions via titratable promoter alleles

21 January 2018

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The relative merits of the tetO2 and tetO7 promoter systems for the functional analysis of heterologous genes in yeast and a compilation of essential yeast genes with tetO2 promoter substitutions.

21 January 2018

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Parallel analysis of mutant human glucose 6-phosphate dehydrogenase in yeast using PCR colonies

21 January 2018

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High-throughput cell-based assays in yeast

21 January 2018

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21 January 2018

Yeast and drug discovery

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From genetics and genomics to drug discovery: yeast rises to the challenge

21 January 2018

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Yeast as a model for medical and medicinal research

21 January 2018

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From gene to screen with yeast

21 January 2018

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Functional genomics: lessons from yeast

21 January 2018

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Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants

21 January 2018

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Methods of assaying Bcl-2 and Bax family proteins in yeast

21 January 2018

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Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

21 January 2018

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Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells

21 January 2018

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Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

21 January 2018

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G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery

21 January 2018

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Yeast Assays for G-Protein-Coupled Receptors

21 January 2018

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Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid

21 January 2018

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Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays

21 January 2018

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Functional Assays for Identifying Ligands at Orphan G Protein-Coupled Receptors

21 January 2018

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Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling

21 January 2018

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Evaluation of a recombinant yeast cell estrogen screening assay

21 January 2018

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Development of a rapid yeast estrogen bioassay, based on the expression of green fluorescent protein.

21 January 2018

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A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens

21 January 2018

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Isolation of drugs active against mammalian prions using a yeast-based screening assay

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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Clinical evaluation of p53 mutations in urothelial carcinoma by IHC and FASAY.

21 January 2018

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Detection of TP53 mutation in ameloblastoma by the use of a yeast functional assay

21 January 2018

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Loss of p53 transcriptional activity in hepatocellular carcinoma evaluated by yeast-based functional assay: comparison with p53 immunohistochemistry

21 January 2018

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A simple p53 functional assay for screening cell lines, blood, and tumors

21 January 2018

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Mass spectrometry-based proteomics turns quantitative

21 January 2018

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Biomarkers for amyotrophic lateral sclerosis

21 January 2018

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Metabolic profiling of patients with schizophrenia

21 January 2018

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A Robust Toolkit for Functional Profiling of the Yeast Genome

21 January 2018

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Probabilistic model of the human protein-protein interaction network

21 January 2018

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Sequencers step up to the speed challenge

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B709494A

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17 August 2017

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