Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes (Q37036031)

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scientific article published on 08 December 2008

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English	Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes	scientific article published on 08 December 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes (English)

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Europe PubMed Central

PMC publication ID

17 August 2017

17

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17 August 2017

Stephan C Collins

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Stephan Collins

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Roger Cox

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Jens C Brüning

18

object named as

Jens C Brüning

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17 August 2017

Fernando Abdulkader

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Fernando Abdulkader

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17 August 2017

author name string

Christophe A Girard

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17 August 2017

F Thomas Wunderlich

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17 August 2017

Kenju Shimomura

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17 August 2017

Stephan Kaizik

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17 August 2017

Peter Proks

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17 August 2017

Anne Clark

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17 August 2017

Vicky Ball

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17 August 2017

Lejla Zubcevic

10

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17 August 2017

Liz Bentley

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17 August 2017

Rebecca Clark

12

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17 August 2017

Chris Church

13

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17 August 2017

Alison Hugill

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17 August 2017

Juris Galvanovskis

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17 August 2017

Frances M Ashcroft

19

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17 August 2017

language of work or name

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publication date

8 December 2008

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17 August 2017

Journal of Clinical Investigation

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17 August 2017

119

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17 August 2017

1

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17 August 2017

80-90

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17 August 2017

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

KATP channels as molecular sensors of cellular metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Roles of KATP channels as metabolic sensors in acute metabolic changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Sulphonylurea action revisited: the post-cloning era.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Adenosine diphosphate as an intracellular regulator of insulin secretion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

29 September 2017

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

27 June 2018

The Walter B. Cannon Physiology in Perspective Lecture, 2007. ATP-sensitive K+ channels and disease: from molecule to malady

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Activating mutations in the gene encoding Kir6.2 alter fetal and postnatal growth and also cause neonatal diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 September 2018

Improved motor development and good long-term glycaemic control with sulfonylurea treatment in a patient with the syndrome of intermediate developmental delay, early-onset generalised epilepsy and neonatal diabetes associated with the V59M mutation i

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 December 2018

Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613450

4 December 2018

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of ATP-insensitive KATP channels in pancreatic beta-cells underlies a spectrum of diabetic phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19065048

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI35772

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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