Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features (Q24320031)

GOA release 2020-03-11

response to ATP

1 reference

GOA release 2020-03-11

Anna L Gloyn

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Andrew Tym Hattersley

object named as

Andrew T Hattersley

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Frances Ashcroft

object named as

Frances M Ashcroft

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author name string

Peter Proks

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Jennifer F Antcliff

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Jon Lippiat

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

14 December 2004

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published in

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volume

101

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issue

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page(s)

17539-44

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cites work

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

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Molecular mechanism for ATP-dependent closure of the K+ channel Kir6.2

19 March 2017

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Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor

19 March 2017

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Physiological and pathophysiological roles of ATP-sensitive K+ channels

19 March 2017

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Tolerance for ATP-insensitive K(ATP) channels in transgenic mice

19 March 2017

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ATP4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites

19 March 2017

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Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons

19 March 2017

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Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

19 March 2017

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Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

19 March 2017

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Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice

19 March 2017

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Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

19 March 2017

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Type 2 diabetes mellitus: not quite exciting enough?

22 April 2017

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Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

27 September 2017

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27 September 2017

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Membrane phospholipid control of nucleotide sensitivity of KATP channels

27 September 2017

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Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.

27 September 2017

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Octameric Stoichiometry of the KATP Channel Complex

27 September 2017

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Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain

27 September 2017

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Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel subunit expressed in pancreatic beta-cells, brain, heart and skeletal muscle

27 September 2017

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Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes

27 September 2017

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Linkage of type 2 diabetes to the glucokinase gene

30 May 2018

1 reference

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Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients

30 May 2018

1 reference

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Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

21 January 2018

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Neurotensin Inhibition of the Hyperpolarization‐Activated Cation Current (Ih) in the Rat Substantia Nigra Pars Compacta Implicates the Protein Kinase C Pathway

21 January 2018

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

1 reference

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K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

21 January 2018

1 reference

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Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain

21 January 2018

1 reference

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Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels.

21 January 2018

1 reference

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Phospholipids as modulators of K(ATP) channels: distinct mechanisms for control of sensitivity to sulphonylureas, K(+) channel openers, and ATP.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=536014

Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.

29 November 2018

1 reference

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The changes in adenine nucleotides measured in glucose-stimulated rodent islets occur in beta cells but not in alpha cells and are also observed in human islets

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15583126

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0404756101

1 reference

ADS bibcode

2004PNAS..10117539P

0 references

1 reference

1 reference

PubMed publication ID

15583126

1 reference