Genetic reconstitution of tumorigenesis in primary intestinal cells (Q36990814)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Genetic reconstitution of tumorigenesis in primary intestinal cells (English)

1 reference

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3 March 2020

1 reference

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3 March 2020

Hitoshi Nakagama

1 reference

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3 March 2020

Masako Ochiai

1 reference

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3 March 2020

Kunishige Onuma

1 reference

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3 March 2020

Kaoru Orihashi

series ordinal

1 reference

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3 March 2020

Toshio Imai

series ordinal

1 reference

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3 March 2020

Yoshitaka Hippo

series ordinal

1 reference

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3 March 2020

language of work or name

English

0 references

publication date

17 June 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

3 March 2020

published in

1 reference

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3 March 2020

volume

110

1 reference

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3 March 2020

issue

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3 March 2020

page(s)

11127-11132

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

3 March 2020

cites work

1 reference

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Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer

29 September 2017

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Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas

29 September 2017

1 reference

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Comprehensive molecular characterization of human colon and rectal cancer

29 September 2017

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The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor

29 September 2017

1 reference

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The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

29 September 2017

1 reference

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Controlled gene expression in primary Lgr5 organoid cultures

29 September 2017

1 reference

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Interconversion between intestinal stem cell populations in distinct niches

29 September 2017

1 reference

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Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion

29 September 2017

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Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool

29 September 2017

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Eyes wide open: a critical review of sphere-formation as an assay for stem cells

29 September 2017

1 reference

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Epithelial Tissues Have Varying Degrees of Susceptibility to KrasG12D-Initiated Tumorigenesis in a Mouse Model

29 September 2017

1 reference

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Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

29 September 2017

1 reference

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Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Molecular origins of cancer: Molecular basis of colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Genetic prognostic and predictive markers in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Colorectal carcinogenesis: Review of human and experimental animal studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Mouse models of colon cancer

29 September 2017

1 reference

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A transposon-based genetic screen in mice identifies genes altered in colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Crypt stem cells as the cells-of-origin of intestinal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

The pleiotropic phenotype of Apc mutations in the mouse: allele specificity and effects of the genetic background.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis

29 September 2017

1 reference

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Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin

29 September 2017

1 reference

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Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

29 September 2017

1 reference

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APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

29 September 2017

1 reference

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Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

29 September 2017

1 reference

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Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.

29 September 2017

1 reference

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Effects of p 53 mutations on apoptosis in mouse intestinal and human colonic adenomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703980

Structure and dynamics of a primordial catalytic fold generated by in vitro evolution

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1221926110

Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23776211

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23776211

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23776211

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1221926110

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

23776211

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776211%20AND%20SRC:MED&resulttype=core&format=json