Genetics of type 2 diabetes mellitus and obesity--a review (Q36977820)

17 August 2017

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title

Genetics of type 2 diabetes mellitus and obesity--a review (English)

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17 August 2017

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Mark I McCarthy

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Bahram Jafar-Mohammadi

series ordinal

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17 August 2017

language of work or name

English

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publication date

1 January 2008

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17 August 2017

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

2-10

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Global and societal implications of the diabetes epidemic

17 August 2017

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Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young

21 January 2018

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Microsatellite polymorphisms at the glucokinase locus: a population association study in Caucasian type 2 diabetic subjects

21 January 2018

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Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

21 January 2018

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

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Genetic cause of hyperglycaemia and response to treatment in diabetes

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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

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Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

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Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations

21 January 2018

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Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations

21 January 2018

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

21 January 2018

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Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction

21 January 2018

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beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

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Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

21 January 2018

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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

21 January 2018

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A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes

21 January 2018

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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

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Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

21 January 2018

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Functional effects of mutations at F35 in the NH2-terminus of Kir6.2 (KCNJ11), causing neonatal diabetes, and response to sulfonylurea therapy

21 January 2018

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Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers

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Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification

21 January 2018

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A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

21 January 2018

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

21 January 2018

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Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

21 January 2018

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Molecular genetics of human obesity-associated MC4R mutations

21 January 2018

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Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations

21 January 2018

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

21 January 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

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Assessing the probability that a positive report is false: an approach for molecular epidemiology studies

21 January 2018

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The human obesity gene map: the 2005 update

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Genomic Priorities and Public Health

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New methods for finding disease-susceptibility genes: impact and potential

21 January 2018

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

21 January 2018

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

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Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

21 January 2018

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The genetics of human obesity

21 January 2018

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Obesity – is it a genetic disorder?

21 January 2018

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The future of genetic studies of complex human diseases

21 January 2018

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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

21 January 2018

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PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

21 January 2018

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Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene

21 January 2018

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Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects

21 January 2018

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GAD2 on chromosome 10p12 is a candidate gene for human obesity

21 January 2018

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Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?

21 January 2018

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

21 January 2018

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Lack of support for the association between GAD2 polymorphisms and severe human obesity

21 January 2018

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The International HapMap Project

21 January 2018

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21 January 2018

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Highly parallel genomic assays

21 January 2018

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TCF7L2: the biggest story in diabetes genetics since HLA?

21 January 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

21 January 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

21 January 2018

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

21 January 2018

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

21 January 2018

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A genome-wide association study identifies novel risk loci for type 2 diabetes

21 January 2018

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Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity

21 January 2018

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p16INK4a induces an age-dependent decline in islet regenerative potential

21 January 2018

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A common genetic variant is associated with adult and childhood obesity

21 January 2018

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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

21 January 2018

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Variation in FTO contributes to childhood obesity and severe adult obesity

21 January 2018

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An imprinted locus associated with transient neonatal diabetes mellitus

21 January 2018

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Significant Linkage of BMI to Chromosome 10p in the U.K. Population and Evaluation of GAD2 as a Positional Candidate

21 January 2018

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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

21 January 2018

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Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

21 January 2018

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What makes a good genetic association study?

21 January 2018

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Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

21 January 2018

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COCI

https://opencitations.net/index/coci/api/v1/citations/10.1038/47254

10.1080/07853890701670421

15 July 2023

Identifiers

DOI

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17 August 2017

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