Innate immunity: the missing link in neuroprotection and neurodegeneration? (Q34627260)

3 August 2017

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title

Innate immunity: the missing link in neuroprotection and neurodegeneration? (English)

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3 August 2017

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Jean-Pierre Julien

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3 August 2017

Minh Dang Nguyen

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3 August 2017

Serge Rivest

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 March 2002

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Nature Reviews Neuroscience

3 August 2017

published in

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

216-227

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Toll signaling pathways in the innate immune response

3 August 2017

cites work

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Toll, a new piece in the puzzle of innate immunity

31 March 2020

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Toll-like receptors: critical proteins linking innate and acquired immunity

31 March 2020

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Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes.

31 March 2020

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Tlr4: central component of the sole mammalian LPS sensor

31 March 2020

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

31 March 2020

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

31 March 2020

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A Toll-like receptor recognizes bacterial DNA

31 March 2020

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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

31 March 2020

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors

31 March 2020

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JNK2 and IKKbeta are required for activating the innate response to viral infection

31 March 2020

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Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

31 March 2020

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

31 March 2020

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The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations

31 March 2020

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Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components

31 March 2020

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Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS.

31 March 2020

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Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge

31 March 2020

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Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia

31 March 2020

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Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide

31 March 2020

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Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines

31 March 2020

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Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration.

31 March 2020

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Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia

31 March 2020

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Bacterial endotoxin sensitizes the immature brain to hypoxic--ischaemic injury

31 March 2020

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Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor

31 March 2020

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Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord

31 March 2020

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Cellular reactions at the lesion site after crushing of the rat optic nerve

31 March 2020

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Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis

31 March 2020

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Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain

31 March 2020

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Interleukin-1beta promotes repair of the CNS.

31 March 2020

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RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

31 March 2020

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TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination

31 March 2020

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IFNgamma enhances microglial reactions to hippocampal axonal degeneration

31 March 2020

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Microglia as mediators of inflammatory and degenerative diseases

31 March 2020

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Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

31 March 2020

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Tumor necrosis factor-alpha in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system

31 March 2020

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Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

31 March 2020

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Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha

31 March 2020

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Cytokines and acute neurodegeneration

31 March 2020

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Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

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Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.

31 March 2020

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Induction of MHC class I genes in neurons

31 March 2020

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Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha

31 March 2020

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Regulation of class I MHC gene expression in the developing and mature CNS by neural activity

31 March 2020

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Immunologic complexity in neurons

31 March 2020

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Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration

31 March 2020

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Synaptic autoimmunity and the Salk factor

31 March 2020

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Autoimmunity and neurological disease: antibody modulation of synaptic transmission

31 March 2020

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Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins

31 March 2020

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Glutamate receptor GluR3 antibodies and death of cortical cells

31 March 2020

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Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons

31 March 2020

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Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain.

31 March 2020

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The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo

31 March 2020

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The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies

31 March 2020

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Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

31 March 2020

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Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability

31 March 2020

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Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis.

31 March 2020

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Altered calcium homeostasis and ultrastructure in motoneurons of mice caused by passively transferred anti-motoneuronal IgG

31 March 2020

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Ultrastructural analysis of spinal motoneurones from mice treated with IgG from ALS patients, healthy individuals, or disease controls

31 March 2020

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Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG

31 March 2020

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Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis

31 March 2020

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Autoimmunity to munc-18 in Rasmussen's encephalitis.

31 March 2020

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The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer

31 March 2020

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Autoimmunity to gephyrin in Stiff-Man syndrome

31 March 2020

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Tumor-specific killer cells in paraneoplastic cerebellar degeneration

31 March 2020

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Immunoglobulin G and complement immunoreactivity in the cerebral cortex of patients with Rasmussen's encephalitis

31 March 2020

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Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration

31 March 2020

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Immunity assessment in the early stages of amyotrophic lateral sclerosis: a study of virus antibodies and lymphocyte subsets

31 March 2020

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Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis

31 March 2020

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Immunohistochemical characterization of the inflammatory infiltrate in amyotrophic lateral sclerosis

31 March 2020

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T Cell Receptor BV Gene Rearrangements in the Spinal Cords and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

31 March 2020

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Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier

31 March 2020

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Intravascular infusions of soluble beta-amyloid compromise the blood-brain barrier, activate CNS glial cells and induce peripheral hemorrhage

31 March 2020

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Increased blood-brain barrier permeability and endothelial abnormalities induced by vascular endothelial growth factor.

31 March 2020

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VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain

31 March 2020

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Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain

31 March 2020

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Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

31 March 2020

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An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy

31 March 2020

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Reversible ALS-like disorder in HIV infection

31 March 2020

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31 March 2020

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HTLV tax-rex DNA and antibodies in idiopathic amyotrophic lateral sclerosis

31 March 2020

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Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS

31 March 2020

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Viral encephalitis in children.

31 March 2020

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Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus

31 March 2020

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Spatial memory and learning deficits after experimental pneumococcal meningitis in mice

31 March 2020

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LP-BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor

31 March 2020

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Age-dependent poliomyelitis in mice is associated with respiratory failure and viral replication in the central nervous system and lung

31 March 2020

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The complement system is an integrated part of the natural innate immune response in the brain

31 March 2020

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7 January 2021

Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide

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7 January 2021

Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system

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7 January 2021

Interferon-gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis

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7 January 2021

Identifiers

DOI

10.1038/NRN752

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Dimensions Publication ID

3 August 2017

1048249003

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