Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. (Q36446506)

14 August 2017

Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. (English)

1 reference

14 August 2017

1 reference

C Ullmer

1 reference

14 August 2017

S Zoffmann

1 reference

14 August 2017

B Bohrmann

1 reference

14 August 2017

H Matile

1 reference

14 August 2017

L Lindemann

1 reference

14 August 2017

Pj Flor

1 reference

14 August 2017

P Malherbe

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 December 2012

1 reference

British Journal of Pharmacology

14 August 2017

1 reference

14 August 2017

167

1 reference

14 August 2017

1 reference

14 August 2017

1448-1466

1 reference

Regulation of N-methyl-D-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7

14 August 2017

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Guide to Receptors and Channels (GRAC), 5th edition

30 September 2017

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor

30 September 2017

1 reference

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance.

30 September 2017

1 reference

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Animal research: reporting in vivo experiments: the ARRIVE guidelines

30 September 2017

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Guidelines for reporting experiments involving animals: the ARRIVE guidelines

30 September 2017

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

30 September 2017

1 reference

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A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists

30 September 2017

1 reference

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Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A.

30 September 2017

1 reference

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beta-arrestin-biased agonism at the beta2-adrenergic receptor

30 September 2017

1 reference

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Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

30 September 2017

1 reference

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Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor.

30 September 2017

1 reference

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Beta-arrestins and cell signaling

30 September 2017

1 reference

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Conformation state-sensitive antibodies to G-protein-coupled receptors

30 September 2017

1 reference

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Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent

30 September 2017

1 reference

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Metabotropic glutamate receptors.

30 September 2017

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ARF proteins: roles in membrane traffic and beyond

30 September 2017

1 reference

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Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis

30 September 2017

1 reference

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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

30 September 2017

1 reference

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A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo

30 September 2017

1 reference

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Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking

30 September 2017

1 reference

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New therapeutic frontiers for metabotropic glutamate receptors

30 September 2017

1 reference

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International Union of Pharmacology. XLVI. G protein-coupled receptor list.

30 September 2017

1 reference

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Transduction of receptor signals by beta-arrestins

30 September 2017

1 reference

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The activation mechanism of class-C G-protein coupled receptors

30 September 2017

1 reference

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

30 September 2017

1 reference

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Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane

30 September 2017

1 reference

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High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus

30 September 2017

1 reference

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Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

30 September 2017

1 reference

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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

30 September 2017

1 reference

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PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

30 September 2017

1 reference

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Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies

30 September 2017

1 reference

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Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

30 September 2017

1 reference

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beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis

30 September 2017

1 reference

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Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes

30 September 2017

1 reference

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Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1.

30 September 2017

1 reference

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

30 September 2017

1 reference

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PICK1 interacts with and regulates PKC phosphorylation of mGLUR7

30 September 2017

1 reference

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Regulation of neurotransmitter release by metabotropic glutamate receptors

30 September 2017

1 reference

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Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence

30 September 2017

1 reference

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Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.

30 September 2017

1 reference

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

30 September 2017

1 reference

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A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7.

30 September 2017

1 reference

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Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion

30 September 2017

1 reference

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

30 September 2017

1 reference

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Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

30 September 2017

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Antibody to epitope tag induces internalization of human muscarinic subtype 1 receptor.

30 September 2017

1 reference

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Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus

30 September 2017

1 reference

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Pharmacology and functions of metabotropic glutamate receptors

30 September 2017

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Morphine activates opioid receptors without causing their rapid internalization

30 September 2017

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Continuous cultures of fused cells secreting antibody of predefined specificity

30 September 2017

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Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

30 September 2017

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ARF6-dependent activation of ERK and Rac1 modulates epithelial tubule development

30 September 2017

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Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders

28 June 2018

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Mapping of calmodulin and Gbetagamma binding domains within the C-terminal region of the metabotropic glutamate receptor 7A.

28 June 2018

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Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state

28 June 2018

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Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study

28 June 2018

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PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding

28 June 2018

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Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes.

21 January 2018

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mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.

21 January 2018

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The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway.

21 January 2018

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The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent

21 January 2018

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The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?

21 January 2018

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AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways

21 January 2018

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Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation.

21 January 2018

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A receptor-G protein coupling-independent step in the internalization of the thyrotropin-releasing hormone receptor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22747985

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22747985

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22747985

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1476-5381.2012.02090.X

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

22747985

1 reference