The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development (Q36258703)

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English	The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

13 August 2017

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development (English)

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Europe PubMed Central

PMC publication ID

13 August 2017

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Chongyang Han

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13 August 2017

Sulayman D Dib-Hajj

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Sulayman D Dib-Hajj

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Europe PubMed Central

PMC publication ID

13 August 2017

Stephen G Waxman

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Stephen G Waxman

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13 August 2017

author name string

Marina N Asiedu

1

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Europe PubMed Central

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13 August 2017

Theodore J Price

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13 August 2017

Gregory Dussor

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Europe PubMed Central

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13 August 2017

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publication date

24 January 2017

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Europe PubMed Central

PMC publication ID

13 August 2017

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Europe PubMed Central

PMC publication ID

13 August 2017

12

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Europe PubMed Central

PMC publication ID

13 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

e0169882

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Europe PubMed Central

PMC publication ID

13 August 2017

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Creative Commons Attribution 4.0 International

24 January 2017

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April 2022 Public Data File from Crossref

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

1 reference

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Sodium channel Nav1.8: Emerging links to human disease

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30 September 2017

Activation of Adenosine Monophosphate-activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain: Involvement of Inhibition on Mitogen-activated Protein Kinase

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30 September 2017

NaV1.9: a sodium channel linked to human pain

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30 September 2017

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.

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Adenosine Monophosphate-activated Protein Kinase Regulates Interleukin-1β Expression and Glial Glutamate Transporter Function in Rodents with Neuropathic Pain

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30 September 2017

Painful peripheral neuropathy and sodium channel mutations

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30 September 2017

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain

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Significant determinants of mouse pain behaviour.

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The anti-diabetic drug metformin protects against chemotherapy-induced peripheral neuropathy in a mouse model

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30 September 2017

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

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mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

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30 September 2017

The Na(V)1.7 sodium channel: from molecule to man.

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30 September 2017

Neurological perspectives on voltage-gated sodium channels.

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30 September 2017

AMP-activated protein kinase: new regulation, new roles?

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30 September 2017

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

1 reference

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30 September 2017

Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

1 reference

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30 September 2017

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes

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30 September 2017

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain

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30 September 2017

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

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30 September 2017

mTOR: from growth signal integration to cancer, diabetes and ageing

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30 September 2017

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability

1 reference

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30 September 2017

Sodium channels in normal and pathological pain

1 reference

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30 September 2017

ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties

1 reference

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30 September 2017

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5261566

30 September 2017

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

1 reference

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30 September 2017

Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes

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30 September 2017

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment

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Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

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ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.

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Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells

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30 September 2017

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

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30 September 2017

The roles of sodium channels in nociception: Implications for mechanisms of pain

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A stop codon mutation in SCN9A causes lack of pain sensation

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30 September 2017

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

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30 September 2017

An SCN9A channelopathy causes congenital inability to experience pain

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Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

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Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7.

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30 September 2017

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

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30 September 2017

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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30 September 2017

Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions

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30 September 2017

Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain

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30 September 2017

Gating properties of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels.

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30 September 2017

Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw.

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30 September 2017

Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat.

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.

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Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

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29 June 2018

Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons

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29 June 2018

Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

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29 June 2018

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

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22 September 2018

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

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22 September 2018

Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.

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22 September 2018

Evidence for the analgesic activity of resveratrol in acute models of nociception in mice

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22 September 2018

Membrane properties and electrogenesis in the distal axons of small dorsal root ganglion neurons in vitro

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A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics

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22 September 2018

Resveratrol inhibits Na+ currents in rat dorsal root ganglion neurons

1 reference

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22 September 2018

Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats

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22 September 2018

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/28118359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/28118359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted biaryl pyrazoles as sodium channel blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/28118359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/28118359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0169882

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

2017PLoSO..1269882A

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

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