Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. (Q36212896)

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11 February 2020

title

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240 (English)

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11 February 2020

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11 February 2020

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11 February 2020

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11 February 2020

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11 February 2020

Ronald A DePinho

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11 February 2020

Robert M Bachoo

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11 February 2020

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Jill Wykosky

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11 February 2020

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David Nathanson

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11 February 2020

Claudio Ponte de Albuquerque

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11 February 2020

Daisuke Kuga

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11 February 2020

Akio Iwanami

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11 February 2020

Julie Dang

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11 February 2020

Huijun Yang

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11 February 2020

Kazuhiro Tanaka

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11 February 2020

Sueli Mieko Oba-Shinjo

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11 February 2020

Miyuki Uno

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11 February 2020

Maria del Mar Inda

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11 February 2020

C David James

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11 February 2020

Scott R Vandenberg

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11 February 2020

Paul S Mischel

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11 February 2020

Webster K Cavenee

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language of work or name

English

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publication date

13 August 2012

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Proceedings of the National Academy of Sciences of the United States of America

11 February 2020

published in

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11 February 2020

volume

109

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issue

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page(s)

14164-14169

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PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

11 February 2020

cites work

1 reference

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A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

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Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

1 October 2017

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Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

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Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

1 October 2017

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

1 October 2017

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Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression

1 October 2017

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Subtle variations in Pten dose determine cancer susceptibility

1 October 2017

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Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

1 October 2017

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1 October 2017

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function

1 October 2017

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Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

1 October 2017

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Post-translational regulation of PTEN.

1 October 2017

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

1 October 2017

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The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration

1 October 2017

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

1 October 2017

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Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

1 October 2017

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

1 October 2017

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In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN.

1 October 2017

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

1 October 2017

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FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway

1 October 2017

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Essential role for nuclear PTEN in maintaining chromosomal integrity

1 October 2017

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Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

1 October 2017

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PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

1 October 2017

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

1 October 2017

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Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast

1 October 2017

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Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis

1 October 2017

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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

1 October 2017

1 reference

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 October 2017

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Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase

1 October 2017

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Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR

1 October 2017

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The phosphoinositide 3-kinase pathway

1 October 2017

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Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay

1 October 2017

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

1 October 2017

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The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells

1 October 2017

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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

1 October 2017

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Profound ligand-independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II

1 October 2017

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Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

1 October 2017

1 reference

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Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3435194

22 September 2018

Identifiers

DOI

10.1073/PNAS.1211962109

1 reference

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11 February 2020

0 references

1 reference

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11 February 2020

PubMed publication ID

22891331

1 reference

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