Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity (Q43955971)

28 November 2017

title

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity (English)

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28 November 2017

Gordon B Mills

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28 November 2017

Dimpy Koul

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28 November 2017

Samar A Jasser

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28 November 2017

Yiling Lu

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28 November 2017

Michael A Davies

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28 November 2017

Ruijun Shen

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28 November 2017

Yuexi Shi

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28 November 2017

W K Alfred Yung

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28 November 2017

language of work or name

English

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publication date

1 April 2002

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28 November 2017

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28 November 2017

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28 November 2017

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28 November 2017

page(s)

2357-2364

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

28 November 2017

cites work

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Pten is essential for embryonic development and tumour suppression

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Src homology domain 2-containing tyrosine phosphatase 2 associates with intercellular adhesion molecule 1 to regulate cell survival

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Phosphorylation of the PTEN tail regulates protein stability and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205296

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205296

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Dimensions Publication ID

28 November 2017

1014851134

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