Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. (Q36208555)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21824272%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells (English)

1 reference

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9 February 2020

0 references

1 reference

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9 February 2020

Michael Y Sherman

1 reference

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9 February 2020

Le Meng

series ordinal

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9 February 2020

Martha Stampfer

series ordinal

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9 February 2020

Julia A Yaglom

series ordinal

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9 February 2020

publication date

16 September 2011

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9 February 2020

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9 February 2020

volume

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9 February 2020

issue

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9 February 2020

page(s)

949-961

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TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

9 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Cellular senescence: putting the paradoxes in perspective

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Jailbreak: oncogene-induced senescence and its evasion

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ of the breast

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Complementary functions of ATM and H2AX in development and suppression of genomic instability

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Cellular senescence: when bad things happen to good cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Oncogene-induced senescence pathways weave an intricate tapestry

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Senescence and serration: a new twist to an old tale

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

BRAFE600-associated senescence-like cell cycle arrest of human naevi

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

DNA end joining becomes less efficient and more error-prone during cellular senescence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

The serial cultivation of human diploid cell strains

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Human epithelial cell immortalization as a step in carcinogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

High frequency of BRAF mutations in nevi

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Senescence of human fibroblasts induced by oncogenic Raf.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Extension of life-span by introduction of telomerase into normal human cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Invasive phenotype of MCF10A cells overexpressing c-Ha-ras and c-erbB-2 oncogenes.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Telomeres shorten during ageing of human fibroblasts

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Tumour biology: senescence in premalignant tumours

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

Oncogene-induced senescence as an initial barrier in lymphoma development

29 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

ATR and H2AX cooperate in maintaining genome stability under replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Executing Cell Senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2011.00736.X

Executing cell senescence

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3433764

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21824272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21824272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21824272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1474-9726.2011.00736.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21824272%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21824272%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

21824272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21824272%20AND%20SRC:MED&resulttype=core&format=json