Cellular senescence: when bad things happen to good cells (Q29615561)

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2 January 2020

review article

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title

Cellular senescence: when bad things happen to good cells (English)

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PubMed

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30 April 2017

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2 January 2020

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Fabrizio Daddadifagagna

series ordinal

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2 January 2020

Judith Campisi

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30 April 2017

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1 September 2007

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Nature Reviews Molecular Cell Biology

2 January 2020

published in

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2 January 2020

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2 January 2020

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729-740

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

2 January 2020

cites work

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Cancer: the rise of the genetic paradigm

31 March 2020

1 reference

Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice

31 March 2020

1 reference

Senescence as a mode of tumor suppression

31 March 2020

1 reference

Cellular senescence as a tumor-suppressor mechanism

31 March 2020

1 reference

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

31 March 2020

1 reference

Cancer and ageing: rival demons?

31 March 2020

1 reference

31 March 2020

1 reference

What has senescence got to do with cancer?

31 March 2020

1 reference

Cellular senescence as a tumor-protection mechanism: the essential role of counting

31 March 2020

1 reference

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

31 March 2020

1 reference

Cellular senescence and tissue aging in vivo

31 March 2020

1 reference

The regulation of INK4/ARF in cancer and aging

31 March 2020

1 reference

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

31 March 2020

1 reference

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

31 March 2020

1 reference

Human fibroblast commitment to a senescence-like state in response to histone deacetylase inhibitors is cell cycle dependent

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

31 March 2020

1 reference

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

1 reference

Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion

31 March 2020

1 reference

Senescence of human fibroblasts induced by oncogenic Raf.

31 March 2020

1 reference

Hallmarks of senescence in carcinogenesis and cancer therapy

31 March 2020

1 reference

Mechanisms of cellular senescence in human and mouse cells.

31 March 2020

1 reference

Mechanisms and Functions of Cell Death

31 March 2020

1 reference

A matter of life and death

31 March 2020

1 reference

Differential regulation of apoptotic cell death in senescent human cells.

31 March 2020

1 reference

Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts

31 March 2020

1 reference

Caspase inhibition switches doxorubicin-induced apoptosis to senescence

31 March 2020

1 reference

Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.

31 March 2020

1 reference

Bcl-2 activates a programme of premature senescence in human carcinoma cells

31 March 2020

1 reference

Senescent fibroblasts resist apoptosis by downregulating caspase-3.

31 March 2020

1 reference

Death-associated protein 3 regulates cellular senescence through oxidative stress response.

31 March 2020

1 reference

p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts

31 March 2020

1 reference

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

31 March 2020

1 reference

Molecular signature of oncogenic ras-induced senescence.

31 March 2020

1 reference

Microarray analysis of replicative senescence

31 March 2020

1 reference

Identification of differentially expressed proteins in senescent human embryonic fibroblasts

31 March 2020

1 reference

Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology

31 March 2020

1 reference

Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci

31 March 2020

1 reference

The RB and p53 pathways in cancer

31 March 2020

1 reference

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

31 March 2020

1 reference

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

31 March 2020

1 reference

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

31 March 2020

1 reference

Global change of gene expression at late G1/S boundary may occur in human IMR-90 diploid fibroblasts during senescence

31 March 2020

1 reference

Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

31 March 2020

1 reference

Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation

31 March 2020

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

31 March 2020

1 reference

Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

31 March 2020

1 reference

Ink4a/Arf expression is a biomarker of aging

31 March 2020

1 reference

Reversal of human cellular senescence: roles of the p53 and p16 pathways

31 March 2020

1 reference

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

31 March 2020

1 reference

The power and the promise of oncogene-induced senescence markers.

31 March 2020

1 reference

A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

1 reference

DNA damage foci at dysfunctional telomeres

31 March 2020

1 reference

Organisation of complex nuclear domains in somatic mouse cells

31 March 2020

1 reference

Functional links between telomeres and proteins of the DNA-damage response

31 March 2020

1 reference

Mammalian telomeres end in a large duplex loop

31 March 2020

1 reference

Telomeres shorten during ageing of human fibroblasts

31 March 2020

1 reference

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

31 March 2020

1 reference

Accumulation of short telomeres in human fibroblasts prior to replicative senescence

31 March 2020

1 reference

DNA damage checkpoint kinase Chk2 triggers replicative senescence

31 March 2020

1 reference

Telomerase in the human organism

31 March 2020

1 reference

In vitro senescence of immune cells

31 March 2020

1 reference

Telomerase maintains telomere structure in normal human cells.

31 March 2020

1 reference

Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

1 reference

Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts

31 March 2020

1 reference

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

31 March 2020

1 reference

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

31 March 2020

1 reference

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

31 March 2020

1 reference

Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

31 March 2020

1 reference

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

1 reference

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

31 March 2020

1 reference

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

31 March 2020

1 reference

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

31 March 2020

1 reference

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

31 March 2020

1 reference

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

31 March 2020

1 reference

BRAFE600-associated senescence-like cell cycle arrest of human naevi

31 March 2020

1 reference

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

31 March 2020

1 reference

Lack of replicative senescence in normal rodent glia

31 March 2020

1 reference

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

31 March 2020

1 reference

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

31 March 2020

1 reference

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

31 March 2020

1 reference

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

31 March 2020

1 reference

Normal human fibroblasts are resistant to RAS-induced senescence

31 March 2020

1 reference

Opposing effects of mutant ras oncoprotein on human fibroblast and epithelial cell proliferation: implications for models of human tumorigenesis

31 March 2020

1 reference

Oncogene-induced senescence as an initial barrier in lymphoma development

31 March 2020

1 reference

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

31 March 2020

1 reference

Tumour biology: senescence in premalignant tumours

31 March 2020

1 reference

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

31 March 2020

1 reference

DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation

31 March 2020

1 reference

Smurf2 up-regulation activates telomere-dependent senescence

31 March 2020

1 reference

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

31 March 2020

1 reference

Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation

31 March 2020

1 reference

Developmental differences in the immortalization of lung fibroblasts by telomerase

31 March 2020

1 reference

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

31 March 2020

1 reference

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

31 March 2020

1 reference

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

31 March 2020

1 reference

p16INK4a induces an age-dependent decline in islet regenerative potential

31 March 2020

1 reference

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

31 March 2020

1 reference

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

31 March 2020

1 reference

RETRACTED: Small molecule-based reversible reprogramming of cellular lifespan

31 March 2020

1 reference

Senescence and immortalization: role of telomeres and telomerase

31 March 2020

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

1 reference

Different telomere damage signaling pathways in human and mouse cells

31 March 2020

1 reference

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

31 March 2020

1 reference

CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

p19ARF links the tumour suppressor p53 to Ras

31 March 2020

1 reference

p16INK4a modulates p53 in primary human mammary epithelial cells.

31 March 2020

1 reference

Loss of linker histone H1 in cellular senescence

31 March 2020

1 reference

Molecular dissection of formation of senescence-associated heterochromatin foci

31 March 2020

1 reference

Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes

31 March 2020

1 reference

Accumulation of senescent cells in mitotic tissue of aging primates

31 March 2020

1 reference

Telomere length and replicative aging in human vascular tissues

31 March 2020

1 reference

The role of chondrocyte senescence in osteoarthritis

31 March 2020

1 reference

Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

31 March 2020

1 reference

Cellular senescence in the pathogenesis of benign prostatic hyperplasia

31 March 2020

1 reference

Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

31 March 2020

1 reference

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

1 reference

Short telomeres limit tumor progression in vivo by inducing senescence

31 March 2020

1 reference

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

1 reference

Li-Fraumeni syndrome: a p53 family affair

31 March 2020

1 reference

Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome

31 March 2020

1 reference

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

31 March 2020

1 reference

The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

31 March 2020

1 reference

Creation of human tumour cells with defined genetic elements

31 March 2020

1 reference

p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

1 reference

Modulation of mammalian life span by the short isoform of p53.

31 March 2020

1 reference

Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

31 March 2020

1 reference

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

31 March 2020

1 reference

The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms

31 March 2020

1 reference

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

31 March 2020

1 reference

Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity

31 March 2020

1 reference

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

31 March 2020

1 reference

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

31 March 2020

1 reference

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

31 March 2020

1 reference

Tumor suppression and normal aging in mice with constitutively high p53 activity

31 March 2020

1 reference

Defining the molecular mechanisms of human cell immortalization

31 March 2020

1 reference

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

31 March 2020

1 reference

Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells

31 March 2020

1 reference

Muscle stem cells in development, regeneration, and disease

31 March 2020

1 reference

Potential of stem-cell-based therapies for heart disease

31 March 2020

1 reference

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31 March 2020

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2 January 2020

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