Proline hydroxylation and gene expression (Q36161153)

12 August 2017

1 reference

title

Proline hydroxylation and gene expression (English)

1 reference

12 August 2017

main subject

proline hydroxylation

0 references

William G Kaelin

1 reference

12 August 2017

publication date

1 January 2005

1 reference

Annual Review of Biochemistry

12 August 2017

1 reference

inferred from page(s)

published in

1 reference

12 August 2017

1 reference

12 August 2017

page(s)

115-128

1 reference

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

12 August 2017

cites work

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Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells

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Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

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12 October 2022

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Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

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12 October 2022

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Prolyl 4-hydroxylase, a target enzyme for drug development. Design of suppressive agents and the in vitro effects of inhibitors and proinhibitors

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12 October 2022

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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12 October 2022

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Role of hydrogen peroxide in hypoxia-induced erythropoietin production

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Characterization and comparative analysis of the EGLN gene family

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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

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HIF-1alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway

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Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth

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Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling

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Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene

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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

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Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

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Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila

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12 October 2022

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Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species

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Perspectives on oxygen sensing

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Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

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The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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12 October 2022

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Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

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12 October 2022

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Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

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12 October 2022

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

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Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

1 reference

12 October 2022

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Metabolism of Proline and the Hydroxyprolines

1 reference

12 October 2022

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Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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12 October 2022

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Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death

1 reference

12 October 2022

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia upregulates inducible (Type II) nitric oxide synthase in an HIF-1 dependent manner in rat pulmonary microvascular but not aortic smooth muscle cells

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12 October 2022

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

12 October 2022

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Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

von Hippel-Lindau disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Molecular basis of the VHL hereditary cancer syndrome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Identification and characterization of a nuclease specific for the 3' end of the U6 small nuclear RNA

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Putative Control of Angiogenesis in Hemangioblastomas by the von Hippel-Lindau Tumor Suppressor Gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Accumulation of HIF-1alpha under the influence of nitric oxide.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

12 October 2022

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TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Activation of HIF-1alpha mRNA by hypoxia and iron chelator in isolated rat carotid body

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1146/ANNUREV.BIOCHEM.74.082803.133142

Identifiers

DOI

10.1146/ANNUREV.BIOCHEM.74.082803.133142

1 reference

12 August 2017

1 reference