Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway (Q24672316)

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J Gu

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M Schau

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H F Bunn

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

7 July 1998

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published in

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volume

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issue

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page(s)

7987-92

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cites work

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

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Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

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Structure and functions of the 20S and 26S proteasomes

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Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)

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Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex

7 April 2017

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

7 April 2017

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

7 April 2017

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

7 April 2017

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Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

7 April 2017

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Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

7 April 2017

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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

7 April 2017

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Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

7 April 2017

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

7 April 2017

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Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

7 April 2017

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Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

7 April 2017

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Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

7 April 2017

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

7 April 2017

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PEST sequences and regulation by proteolysis

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The ubiquitin-proteasome proteolytic pathway

7 April 2017

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The aryl hydrocarbon receptor complex

7 April 2017

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The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins

7 April 2017

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

28 September 2017

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

28 September 2017

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Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

28 September 2017

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Oxygen sensing and molecular adaptation to hypoxia

28 September 2017

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28 September 2017

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Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

28 September 2017

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Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

28 September 2017

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Potent transactivation domains of the Ah receptor and the Ah receptor nuclear translocator map to their carboxyl termini.

28 September 2017

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Transcriptional activation function of the mouse Ah receptor nuclear translocator.

28 September 2017

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Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases

28 September 2017

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Proteasomes: destruction as a programme

28 September 2017

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Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

28 September 2017

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The hypoxic response: huffing and HIFing

28 September 2017

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Mutations of conserved cysteine residues in the CWLC motif of the oncoretrovirus SU protein affect maturation and translocation

28 September 2017

1 reference

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PAS is a dimerization domain common to Drosophila period and several transcription factors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=20916

Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9653127

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9653127

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.95.14.7987

1 reference

ADS bibcode

1998PNAS...95.7987H

0 references

1 reference

1 reference

PubMed publication ID

9653127

1 reference